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Description of the medicine: Biperiden (Biperiden)

BIPERIDENE (Biperiden).
1- [Bicyclo (2.2.1) hept-5-en-3-yl] -1-phenyl-3-piperidino-1-propanol.

Available in the form of hydrochloride and lactate.

Synonyms: Akineton, Akineton, Dekinet, Ipsatol, Paraden, Tasmolin.

White crystalline powder. Slightly soluble in water and alcohol.

In structure and pharmacological properties it is close to cyclodol.

When administered orally, the bioavailability is about 30%, Cmax - 1 / 2-2 hours; excreted in the form of metabolites with urine and feces.

It is prescribed for parkinsonism and extrapyramidal disorders caused by antipsychotics.

Applied orally or parenterally (intramuscularly or intravenously).

Inside, adults are prescribed starting with 0.001 g (1 mg) 2 times a day; if necessary, the daily dose is increased daily by 0.002 g (2 mg) to a maximum daily dose of 0.016 g (in 2-4 doses); for extrapyramidal disorders caused by antipsychotics, 0.001-0.004 g (1-4 mg) are used. Children are prescribed at the rate of 0.001-0.002 (1-2 mg) 1-3 times a day.

Parenteral administration of 0.0025-0.005 g (0.5-1 ml of 0.5% solution); if necessary, repeat administration after 30 minutes.

Possible side effects are basically the same as when using cyclodol. Unlike the latter, drowsiness is sometimes noted; injections of biperiden in some cases cause arterial hypotension.

Enhances the effects of other anticholinergics, antihistamines, anticonvulsants and antiparkinsonian drugs.

Incompatible with alcohol.

Method of release: tablets of 0.002 g (2 mg) (N. 20) and tablets of retard 0.004 g (4 mg) (N. 10, 20, 30, 60); 0.5% solution in ampoules of 1 ml (N. 5).

Storage: List B.