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Description of the medicine: Hydroxyzine (Hydroxyzine)

HYDROXYSINE (Hydroxyzine).

2- [2- [4-para-Chloro-A-phenylbenzyl] -1-piperazinyl] ethoxy] ethanol.

Available in the form of hydrochloride.

Synonyms: Atarax, Alamon, Arcanax, Atara, Atarax, Atazin, Clorixin, Disron, Durrax, Forticalman, Hyzine, Iremoxin, Multipax, Neocalma, Neurolax, Orgatrax, Placidol, Quiess, Ucerax.

Hydroxyzine was one of the first blockers of H1-histamine receptors. However, it has a sedative and anxiolytic effect; possesses m-anticholinergic and antiemetic properties.

The chemical structure is close to some modern anti-histamine drugs (see Cetirizine), but as an anti-histamine (anti-allergic) agent, it is currently not widely used, but has become used as a relatively “mild” tranquilizing agent.

When taken orally, it is absorbed quickly, Cmax is 2 hours, T Ѕ - 12-24 hours.

Indications for use are mainly irritability, tension, a sense of fear, alcohol withdrawal syndrome, and sedation. It is also used (in connection with antihistamine activity) for pruritic dermatoses.

There is evidence of the effectiveness of hydroxyzine in cardiac neurotic disorders.

Inside, adults are prescribed 0.01 or 0.025 g (10 or 25 mg) in a total daily dose of 0.025-0.1 g (25-100 mg), and if necessary, up to 0.3 g per day; children are administered at a rate of 1 mg / kg per day (in several doses). Usually used within 4 weeks. In anesthesiology, 0.1-0.2 g is prescribed at bedtime on the eve of surgery.

In cases of acute arousal, intramuscular administration is possible (2 ml of a 5% solution - 0.1 g).

When using the drug, drowsiness, general weakness, dizziness, dry mouth and other side effects are sometimes noted.

The drug is contraindicated in renal and liver failure, porphyria, the risk of glaucoma attacks, prostatic hypertrophy (due to the anticholinergic properties of the drug), pregnancy, and breast-feeding.

Method of release: tablets of 0.01 and 0.025 g (10 and 25 mg) (N. 25); 0.2% syrup in 200 ml vials; 5% solution in ampoules of 2 ml (0.1 g).