Medication Description: Hydroxyzine (Hydroxyzine)
2- [2- [4-para-Chloro-A-phenylbenzyl] -1-piperazinyl] ethoxy] ethanol.
Available in the form of hydrochloride.
Synonyms: Atarax, Alamon, Arcanax, Atara, Atarax, Atazin, Clorixin, Disron, Durrax, Forticalman, Hyzine, Iremoxin, Multipax, Neocalma, Neurolax, Orgatrax, Placidol, Quiess, Ucerax.
Hydroxyzine was one of the first blockers of H1-histamine receptors. At the same time, it has a sedative and anxiolytic effect; has m-anticholinergic and antiemetic properties.
The chemical structure is close to some modern anti-histamine drugs (see Cetirizine), but as an anti-histamine (antiallergic) drug, it currently has no widespread use, but has been used as a relatively “soft” tranquilizer.
When ingestion is absorbed quickly, Cmax is 2 hours, T Ѕ - 12-24 hours.
Indications for use are mainly anxiety, tension, feeling of fear, alcohol withdrawal syndrome, premedication. It is also used (in connection with antihistamine activity) for pruritic dermatoses.
There is evidence of the effectiveness of hydroxyzine in cardiac neurotic disorders.
Inside, adults are prescribed for 0.01 or 0.025 g (10 or 25 mg) in a total daily dose of 0.025-0.1 g (25-100 mg), and, if necessary, up to 0.3 g per day; Children are administered at the rate of 1 mg / kg per day (in several doses). Usually used for 4 weeks. In anesthesiology appoint 0.1-0.2 g at bedtime on the eve of the operation.
In cases of acute excitation, intramuscular administration is possible (2 ml of a 5% solution — 0.1 g).
When using the drug, drowsiness, general weakness, dizziness, dry mouth and other side effects are sometimes noted.
The drug is contraindicated in renal and hepatic failure, porphyria, the risk of glaucoma attacks, prostate hypertrophy (due to the anticholinergic properties of the drug), pregnancy, breast-feeding.
Method of production: tablets of 0.01 and 0.025 g (10 and 25 mg) (N. 25); 0.2% syrup in 200 ml bottles; 5% solution in ampoules of 2 ml (0.1 g).