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Description of the medicine: Quetiapine (Quetiapine)

Quetiapine (Quetiapine).

2- [2- (4-Dibenzo [b, f] [1,4] thiazepin-11-yl-1 piperazinyl) ethoxy] ethanol fumarate.

Synonym: Seroquel, Seroquel.

It binds to 5-HT1-serotonin, D1- and D2-dopamine, A-adreno- and H1-histamine receptors.

Quickly and completely absorbed in the digestive tract, T1 / 2 is 7 hours; subjected to intense biotransformation, excreted mainly by the kidneys.

Used for schizophrenia with productive and negative symptoms.

Assign inside, starting with 0.025 g (25 mg) 2 times on the 1st day and increase the single dose to 0.05; 0.1 and 0.15 g, respectively, on days 2,3 and 4; the average daily dose of 0.3 g (300 mg); the maximum is 0.75 g (750 mg).

Possible side effects: sleep disturbances, anxiety, dry mouth, dyspepsia, tachycardia, orthostatic hypotension, myalgia, inhibition of hematopoiesis, increased body temperature, decreased levels of thyroid hormones in the blood, rarely extrapyramidal disorders.

The drug is contraindicated in cases of hematopoiesis, severe liver and kidney diseases, diabetes, hyperthyroidism, pregnancy, breastfeeding.

Release form: tablets on 0,025; 0.1 and 0.2 g (25; 100 and 200 mg) (N. 8, 10 and 10, respectively).

Storage: List B.