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Medication Description: Quetiapine (Quetiapine)

QUETIAPIN (Quetiapine).

2- [2- (4-Dibenzo [b, f] [1,4] thiazepin-11-yl-1 piperazinyl) ethoxy] -ethanol fumarate.

Synonym: Seroquel, Seroquel.

Binds to 5-HT1-serotonin, D1- and D2-dopamine, A-adreno and H1-histamine receptors.

Quickly and completely absorbed in the digestive tract, T1 / 2 is 7 hours; subjected to intense biotransformation, secreted mainly by the kidneys.

Applied with schizophrenia with productive and negative symptoms.

Assign inside, starting with 0.025 g (25 mg), 2 times in the first day and increase the single dose to 0.05; 0.1 and 0.15 g, respectively, in days 2.3 and 4; the average daily dose of 0.3 g (300 mg); the maximum is 0.75 g (750 mg).

Possible side effects: sleep disturbance, anxiety, dry mouth, dyspepsia, tachycardia, orthostatic hypotension, myalgia, hematopoietic suppression, fever, decreased thyroid hormone levels in the blood, rarely extrapyramidal disorders.

The drug is contraindicated in hematopoietic disorders, severe liver and kidney diseases, diabetes, hyperthyroidism, pregnancy, and breastfeeding.

Form release: pills to 0.025; 0.1 and 0.2 g (25; 100 and 200 mg) (N. 8, 10 and 10, respectively).

Storage: List B.