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Medication Description: Levonorgestrel (Levonorgestrel)

Levonorgestrel (Levonorgestrel).

(17α) -13-Ethyl-17-hydroxy-18,19-dipregn-4-ene-20-yn-3-one.

Synonyms: Levonova, Microlut, Mirena, Norplant, Postinor, Levonova, Microlut, Mirena, Norplant, Postinor.

Is a levogyrate isomer of the progestin norgestrel.

The structure is close to norethisterone.

It inhibits the pituitary gonadotropic function - reduces the level of follicle-stimulating and luteinizing hormones, prevents the implantation of a fertilized cell, increases the viscosity of cervical mucus, making it difficult to promote sperm.

When ingestion quickly and completely absorbed in the digestive tract, C max is 2 hours; T Ѕ - 2-7 h; Biotransformation in the liver, excreted in the urine and feces.

Used for contraception (separately and in combination with estrogen - see Combined estrogen-progestin drugs).

Assign inside, subcutaneously (capsules) and intrauterine device.

Inside is used in tablets of 0.75 mg 2 times with an interval of 12 hours (emergency contraception) or administered in 1 tablet (0.75 mg) or 1 tablet (0.03 mg) daily, starting from the 1st day of menstruation within 21 days.

The intrauterine system (Mirena) with levonorgestrel (0.052 g each) is administered on the 4-6 day of the menstrual cycle.

Possible side effects: irregular menstruation, mastalgia, nausea, headache, acne, fluid retention, hirsutism, depression, dermatitis, alopecia.

The drug is contraindicated in hormone-dependent tumors, a tendency to thromboembolism, otosclerosis, acute diseases or tumors of the liver, infections of the genitourinary system.

Method of production: capsules for subcutaneous implantation of 0.036 g (N. 6); tablets of 0.00075 g (0.75 mg) (N. 4); Bean on 0,00003 g (0.03 mg) (N. 35); intrauterine polymeric carriers at 50 µg (with controlled release of levonorgestrel - 20 µg per day).