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Medication Description: Antipyrin (Antipyrinum)

Antipyrinum (Antipyrinum). 1-Phenyl-2, 3-dimethylpyrazolone-5.

Synonyms: Analgesin, Anodynin, Azophen, Methozin, Parodyne, Phenazonum, Phenazone, Phenylon, Pyrazoline, Pyrodin, Sedatin, etc.

Colorless crystals or white crystalline powder; odorless, slightly bitter taste. Very easily soluble in water (1: 1), easily in alcohol. Solutions (pH 6, 0-7, 5) are sterilized at + 120 ° C for 20 minutes.

Antipyrine was one of the first synthetic analgesics, derivatives of pyrazolone, which found application in medicine (1884). With the receipt of other analgesics they began to use relatively rarely. It is not widely used at present. However, it has not completely lost its meaning and is preserved in the nomenclature of drugs.

Like other pyrazolone derivatives, antipyrine has an analgesic, antipyretic and to some extent anti-inflammatory effect. For analgesic and antipyretic activity, drugs of this group are close to salicylic acid derivatives. Pyrazolone derivatives reduce capillary permeability and prevent the development of an inflammatory response. The mechanism of this action is not clear. Effects on the pituitary-adrenal system, these compounds do not have.

The most active anti-inflammatory drug of this group - butadion - inhibits prostaglandin biosynthesis relatively strongly. It belongs to the group of nonsteroidal anti-inflammatory drugs.

Antipyrine has a moderate analgesic, antipyretic and anti-inflammatory effect. When applied topically, there is some hemostatic effect.

Apply antipyrine for neuralgia, colds.

Give adults inside 0.25 - 0.5 g; children older than 6 months - by 0.025 - 0.15 g per reception, depending on age. Take 2 - 3 times a day.

Higher doses for adults inside: single 1 g daily 3 g.

As a hemostatic agent, antipyrine is sometimes used (10–20% solution) for wetting tampons and wipes for nasal and parenchymal hemorrhages.

In the appointment of antipyrine should take into account the possibility of increased sensitivity of patients to the drug with the appearance of urticaria and fixed rash; oppression of blood formation is possible (see. Amidopyrine).

Method of issuance: powder and tablets of 0.25 g.

For use in pediatric practice, tablets of 0.05 are produced; 0.075; 0.1 and 0.15 g

Storage: List B. In a well-closed container, protected from light.

R p.: Tab. Antipyrini 0.25 N. 10

DS 1 tablet 2 - 3 times a day

Rp .: Sol. Antipyrini 10% 30 ml

DS For wetting tampons with nosebleeds

<< Ankofen >> tablets (Tabulettae << Ancophenum >>).

Ingredients: antipyrine and phenacetin at 0.25 g, caffeine sodium benzoate 0.05 g. Analgesic and antipyretic agent. Assign 1 tablet 1 - 2 - 3 times a day.

Storage: List B.