Description of the medicine: Antipyrine (Antipyrinum)
ANTIPYRIN (Antipyrinum). 1-Phenyl-2, 3-dimethylpyrazolone-5.
Synonyms: Analgesin, Anodynin, Azophen, Methozin, Parodyne, Phenazonum, Phenazone, Phenylon, Pyrazoline, Pyrodin, Sedatin, etc.
Colorless crystals or a white crystalline powder; odorless, slightly bitter taste. It is very easily soluble in water (1: 1), easily - in alcohol. Solutions (pH 6, 0 - 7, 5) are sterilized at + 120 ° C for 20 minutes.
Antipyrine was one of the first synthetic analgesics, derivatives of pyrazolone, which were used in medicine (1884). With the receipt of other analgesics, they began to use it relatively rarely. It does not currently have widespread use. However, he did not completely lose the value and remained in the nomenclature of medicines.
Like other pyrazolone derivatives, antipyrine has an analgesic, antipyretic and, to some extent, anti-inflammatory effect. In terms of analgesic and antipyretic activity, drugs of this group are close to salicylic acid derivatives. Derivatives of pyrazolone reduce the permeability of capillaries and prevent the development of an inflammatory reaction. The mechanism of this action is not clear. These compounds do not affect the pituitary - adrenal gland system.
The most active anti-inflammatory drug of this group - butadione - relatively strongly inhibits prostaglandin biosynthesis. He is assigned to the group of non-steroidal anti-inflammatory drugs.
Antipyrine has a moderate analgesic, antipyretic and anti-inflammatory effect. When applied topically, there is some hemostatic effect.
Antipyrine is used for neuralgia, colds.
Give adults inside 0.25 - 0.5 g; children older than 6 months - at 0.025 - 0.15 g per reception, depending on age. Take 2 to 3 times a day.
Higher doses for adults inside: single 1 g, daily 3 g.
As a hemostatic agent, antipyrine is sometimes used (10 - 20% solution) for wetting tampons and wipes in case of nasal and parenchymal bleeding.
When prescribing antipyrine, the possibility of increased sensitivity of patients to the drug with the appearance of urticaria and a fixed rash should be taken into account; suppression of hematopoiesis is possible (see. Amidopyrine).
Method of release: powder and tablets of 0.25 g.
For use in pediatric practice, tablets are available at 0.05; 0.075; 0.1 and 0.15 g.
Storage: List B. In a well-sealed container that protects from the action of light.
Rp.: Tab. Antipyrini 0.25 N. 10
DS 1 tablet 2 to 3 times a day
Rp .: Sol. Antipyrini 10% 30 ml
DS For wetting swabs with nosebleeds
Tablets << Ankofen >> (Tabulettae <<Ancophenum>>).
Composition: antipyrine and phenacetin 0.25 g each, caffeine-benzoate sodium 0.05 g. Analgesic and antipyretic. Assign 1 tablet 1 to 2 - 3 times a day.
Storage: List B.