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Medication Description: Sibutramine (Sibutramine)

Sibutramine (Sibutramine).

(±) - (n-Chlorophenyl) -α-isobutyl-N, N-dimethylcyclobutanemethylamine hydrochloride.

Synonym: Meridia, Meridia.

The chemical structure has similarities with fluoxetine and, like it, has an antidepressant effect. Like fluoxetine, it is an active inhibitor of serotonin reuptake neuronal capture. However, it actively inhibits the reuptake of norepinephrine. Abroad is used as an antidepressant. At the same time, studies conducted abroad and in a number of medical institutions in Russia show that sibutramine has a pronounced anorexigenic activity. A significant part of patients (including those suffering from diabetes), taking it on the background of a low-calorie diet, showed a decrease in body weight (within 3 months) by 5-10%.

Assign inside of 0.005 g (5 mg) 2-3 times a day.

Sibutramine is usually well tolerated. Despite the inhibition of the capture of norepinephrine, pronounced sympathomimetic (and, accordingly, hypertensive), it has no effect (monitoring of arterial pressure, however, is necessary!); possible constipation, insomnia, excessive loss of appetite.

Form release: capsules of 0.01 and 0.015 g (10 and 15 mg).