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Description of medicine: Altretamin (Altretamin)

Altretamin (Altretamin).

N, N, Nґ, Nґ, Nґґ, Nґґ-Hexamethyl-1,3,5-triazine-2,4,6-triamine.

Synonym: Hexalen, Hexalen.

White crystalline powder. It is practically insoluble in water and propylene glycol, soluble in chloroform, ethyl acetate and N, N-dimethylformamide.

Forming covalent bonds with macromolecules, including RNA and DNA, prevents the incorporation of thymidine into DNA.

Quickly and completely absorbed in the digestive tract, C max is 0.5-3 hours, T Ѕ (in the phase of selection) - 4.7-10.2 hours; undergoes biotransformation in the liver, excreted by the kidneys.

Used for ovarian cancer (resistant to cisplatin and alkylating drugs) and small cell lung cancer.

Assign inside (after eating) at 0.26 g / m 2 per day (in 4 divided doses) for 1, 2 or 3 weeks with an interval of 1-4 weeks.

Possible side effects: dyspeptic symptoms, stomatitis, ulceration of the oral mucosa, impaired liver function, moderate leukemia and thrombocytopenia, anemia (rarely), peripheral neuropathy, convulsive reactions.

Contraindications: neurological disorders, pregnancy, breast-feeding, children's age.

Release form: capsules on 0,05 g (50 mg) (N. 10, 40, 60, 80).

Storage: List B.