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Description of the medicine: Zalcitabine (Zalcitabin)

ZALTSITABIN (Zalcitabin).

2 ′, 3′-Dideoxycytidine.

Synonym: Heavid, Hivid.

White or off-white crystalline powder. Soluble in water.

Active against HIV-1 and HIV-2. According to the mechanism of action, it is close to stavudine and other nucleoside preparations (in the cells of the body it undergoes phosphorylation to dideoxycytidine-5′-triphosphate).

When ingested, it is well absorbed, bioavailability is at least 80%, C max - 0.8 hours, T Ѕ - 1-3 hours; undergoes minor biotransformation in the liver, excreted by the kidneys.

Used for HIV infection in adults.

Assign inside 0.75 mg 3 times a day.

Possible side effects: dyspeptic symptoms, anorexia, ulcerative lesions of the esophagus and rectum, impaired liver and kidney function, jaundice, impaired vision and hearing, tachycardia, cardiomyopathy, tremor, convulsions, sleep disturbance, alopecia, anemia, leukopenia, thrombocytopenia, etc.

Contraindications: peripheral neuropathies, erosive and ulcerative esophagitis, pancreatitis, severe violations of the liver and kidneys, cardiomyopathy, severe heart failure, pregnancy, lactation, age up to 13 years.

Release form: tablets on 0,375 and 0,75 mg (N. 20, 100).

Storage: List B.