Description of the medicine: Carboplatin (Carboplatin)
cis-diamino (1,1-cyclobutanedicarboxylate) platinum.
Synonyms: Blastocarb, Kemokarb, Paraplatin, Cycloplatin, Blastocarb, Cycloplatin, Paraplatin.
Crystalline powder. Soluble in water, practically insoluble in ethanol and acetone.
By the mechanism of antitumor action it is similar to cisplatin (see).
It is used for cancer of the ovaries, breast, neck and body of the uterus, testicles, testicles, lung, bladder, osteogenic sarcoma, myeloma and other malignant neoplasms.
It is administered intravenously (within 15-60 min) to adults at the rate of 250-400 mg / m 2 once every 4 weeks or 100 mg / m 2 for 5 days every 4 weeks.
An injection solution is prepared immediately before use in a 5% glucose solution or isotonic sodium chloride solution.
Possible side effects and contraindications are the same as for cisplatin, however carboplatin has less oto-, nephro, and neurotoxic effects, but it significantly inhibits blood formation.
Method of release: lyophilized powder for injection solutions on vials of 0.05; 0.15; 0.2 and 0.45 g; 1% solution for injection in bottles of 5, 15, 45 and 60 ml.