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Medication Description: Sulindac (Sulindac)

SULINDAK (Sulindac). (Z) - 5-Fluoro-2-methyl-1- [para- (methylsulfinyl) benzylidene] inden-3-acetic acid.

Synonyms: Clearonil, Aflodac, Algocetil, Artribid, Artrobid, Clinoril, lisundac, Dorindac, Flusoril, Lindac, MSD-943, Overpon, Reumofil, Sulindor, Sulinid, Sulreuma, Sutalan, etc.

Sulindak is a nonsteroidal anti-inflammatory drug. It has anti-inflammatory, analgesic and antipyretic effects. Like other nonsteroidal anti-inflammatory drugs, inhibits prostaglandin biosynthesis.

Sulindak is quickly absorbed when taken orally and acts for a long time, which allows you to take it 1 - 2 times a day.

In the body, sulindac turns into two major metabolites; sulfone and sulfide. The latter is a strong inhibitor of the formation of prostaglandins and determines the main pharmacological action of sulindac. Thus, sulindac (sulfoxide form) can be considered as a precursor of the active substance (<< prodrug>).

Sulindak is excreted from the body mainly in the form of inactive metabolites and has little effect on the kidney function.

Indications for use are the same as for other modern non-steroidal anti-inflammatory drugs: rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, periarthritis, acute gouty arthritis, lumbago, etc.

Assign sulindak adults inside at a dose of 0.1 - 0.2 g 1 - 2 times a day. The dose is selected individually depending on the effectiveness and tolerability of the drug, but not more than 0.4 g per day. Accepted with meals.

The duration of treatment depends on the severity of the disease and the effectiveness of therapy. In acute gouty arthritis, a 7-day course is usually sufficient.

For children over 2 years old, sulindac is prescribed only for acute rheumatoid arthritis. The initial dose is 4, 5 mg / kg per day (in 2 divided doses with meals). If necessary, increase the daily dose to 6 mg / kg (not more); upon reaching a positive effect, the dose is reduced.

Possible side effects and precautions are basically the same as in the treatment of other non-steroidal anti-inflammatory drugs.

Sulindak is contraindicated in case of gastrointestinal bleeding, a tendency to acute allergic reactions associated with taking other anti-inflammatory drugs, with the development of allergic reactions while taking sulindac, during pregnancy.

Method of production: tablets of 0.1; 0.15 - 0.2 and 0.4 g. For use in pediatric practice, a suspension is also produced containing 0.01 or 0.04 g each (10 or 40 mg of the preparation) in 1 ml.

Storage: List B. In the dark spot.