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Description of the medicine: Sulindac (Sulindac)

SULINDAC (Sulindac). (Z) - 5-Fluoro-2-methyl-1- [para- (methylsulfinyl) benzylidene] indene-3-acetic acid.

Synonyms: Clironil, Aflodac, Algocetil, Artribid, Artrobid, Clinoril, lisundac, Dorindac, Flusoril, Lindac, MSD-943, Overpon, Reumofil, Sulindor, Sulinid, Sulreuma, Sutalan, etc.

Sulindac is a non-steroidal anti-inflammatory drug. It has anti-inflammatory, analgesic and antipyretic effects. Like other non-steroidal anti-inflammatory drugs, it inhibits prostaglandin biosynthesis.

Sulindak is rapidly absorbed when taken orally and acts for a long time, which allows it to be taken 1 to 2 times a day.

In the body, sulindac turns into two main metabolites; sulfone and sulfide. The latter is a strong inhibitor of the formation of prostaglandins and determines the main pharmacological action of sulindac. Thus, sulindac (sulfoxide form) can be considered as a precursor of the active substance (<< prodrug >>).

Sulindac is excreted from the body mainly in the form of inactive metabolites and weakly affects kidney function.

Indications for use are the same as for other modern non-steroidal anti-inflammatory drugs: rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, periarthritis, acute gouty arthritis, lumbago, etc.

Sulindac is prescribed to adults inside at a dose of 0.1 - 0.2 g 1 - 2 times a day. The dose is selected individually depending on the effectiveness and tolerability of the drug, but not more than 0.4 g per day. Take with food.

The duration of treatment depends on the severity of the disease and the effectiveness of therapy. In acute gouty arthritis, a 7-day course is usually sufficient.

For children over 2 years of age, Sulindac is prescribed only for acute rheumatoid arthritis. The initial dose is 4.5 mg / kg per day (in 2 divided doses with meals). If necessary, increase the daily dose to 6 mg / kg (not more); upon reaching a positive effect, the dose is reduced.

Possible side effects and precautions are basically the same as when treated with other non-steroidal anti-inflammatory drugs.

Sulindak is contraindicated in case of gastrointestinal bleeding, a tendency to acute allergic reactions associated with taking other anti-inflammatory drugs, with the development of allergic reactions while taking sulindac, during pregnancy.

Method of release: tablets of 0.1; 0.15 - 0.2 and 0.4 g. For use in pediatric practice, a suspension is also produced containing 0.01 or 0.04 g (10 or 40 mg of the drug) in 1 ml.

Storage: List B. In the dark place.