Description of the medicine: Hexamidin (Hexamidinum)
HEXAMIDIN (Hexamidinum). 5-Ethyl-5-phenylhexahydropyrimidinedione-4, 6.
Synonyms: Primidon, Desoxyphenobarbitone, Lepimidin, Lespiral, Liskantin, Mizodin, Mylepsin, Mysoline, Prilepsin, Primaclone, Primidonum, Primidone, Primoline, Prysoline, Sedilen, Sertan, etc.
White crystalline powder. It is practically insoluble in water, slightly soluble in alcohol.
By chemical structure, it is deoxybarbiturate; differs from phenobarbital in that in position 2 the carbonyl group (C == O) is replaced by methylene (CH2). This chemical modification of the molecule led to the preparation with a strong anticonvulsant effect and less hypnotic effect.
When ingested, hexamidine is rapidly and almost completely absorbed. The peak in plasma concentration is observed after about 3 hours. The half-life in plasma is 7-14 hours. The drug is metabolized with the formation of phenobarbital (about 20%) and another active metabolite - phenylethylmalonamide. About 40% of the unchanged drug is excreted in the urine.
Hexamidine is used mainly for large seizures (grand mal). Less effective for mild abortion and psychiatric equivalents. With small forms of epilepsy, it does not have a permanent effect, but in some cases a therapeutic effect is observed.
Take orally after a meal. The initial daily dose for adults is 0.125 g (in 1 to 2 doses), then the dose is gradually increased to 0.5-1 g per day.
Highest doses for adults: single 0.75 g, daily 2 g.
Children, depending on age, are prescribed from 0.125 to 0.5 g per day.
In the early days of treatment with hexamidine, slight drowsiness, dizziness, headache, ataxia, and nausea are possible. These phenomena usually pass independently. If necessary, the dose is gradually reduced or the drug is canceled, and after a few days prescribed in a reduced dose. Long-term use of hexamidine in large doses can lead to the development of adverse nervous and mental disorders, hematological complications (leukopenia, lymphocytosis, anemia).
Hexamidine enhances the effect of sleeping pills, derivatives of sulfanylurea, cyclophosphamide, methotrexate. Increasing the activity of microsomal liver enzymes, it accelerates the biotransformation of coumarin derivatives, estrogen contraceptives, griseofulvin, doxycycline.
When prescribing hexamidine for pregnant and lactating women, it should be borne in mind that in action it is similar to phenobarbital.
With prolonged use of hexamidine, folic acid deficiency in the body may develop.
The drug is contraindicated for violations of the liver, kidneys, hematopoietic system.
Release form: tablets of 0.125 and 0.25 g in a package of 50 pieces.
Storage: List B. In a well-sealed container.
Abroad under the same name (Hexamidinum, Hexamidine), another drug is produced - 4, 4- (hexamethylenedioxy) -dibenzamidine, which is a chemotherapeutic antiprotozoal agent.