Medication Description: Hexamidinum (Hexamidinum)
Hexamidinum (Hexamidinum). 5-Ethyl-5-phenylhexahydropyrimidine-4, 6.
Synonyms: Primidon, Desoxyphenobarbitone, Lepimidin, Lespiral, Liskantin, Mizodin, Mylepsin, Mysoline, Prilepsin, Primaclone, Primidonum, Primidone, Primoline, Prysoline, Sedilen, Sertan, etc.
White crystalline powder. Practically insoluble in water, slightly soluble in alcohol.
According to the chemical structure is deoxybarbitrate; differs from phenobarbital in that in position 2 the carbonyl group (C == O) is replaced by methylene (CH2). This chemical modification of the molecule led to the preparation of a drug with a strong anticonvulsant effect and a lower hypnotic effect.
When ingestion, hexamidine is rapidly and almost completely absorbed. The peak plasma concentration is observed after about 3 hours. The plasma half-life is 7-14 hours. The drug is metabolized to form phenobarbital (about 20%) and another active metabolite, phenylethylmalonamide. About 40% of the unchanged drug is excreted in the urine.
Hexamidine is used mainly for large convulsive seizures (grand mal). Less effective for mild abortive seizures and mental equivalents. With small forms of epilepsy, it does not have a permanent action, but in some cases a therapeutic effect is observed.
Is ingested after a meal. The initial daily dose for adults is 0.125 g (in 1 - 2 doses), then the dose is gradually increased to 0.5-1 g per day.
Higher doses for adults: a single 0.75 g daily 2 g.
Depending on age, children are prescribed from 0.125 to 0.5 g per day.
In the first days of treatment with hexamidine, slight drowsiness, dizziness, headache, ataxia, nausea are possible. These phenomena usually go away on their own. If necessary, gradually reduce the dose or discontinue the drug, and after a few days prescribed a reduced dose. Prolonged use of hexamidine in large doses can lead to the development of adverse nervous and mental disorders, hematological complications (leukopenia, lymphocytosis, anemia).
Hexamidine enhances the action of hypnotic drugs, sulfonylurea derivatives, cyclophosphamide, methotrexate. Increasing the activity of liver microsomal enzymes, it accelerates the biotransformation of coumarin derivatives, estrogenic contraceptives, griseofulvin, doxycycline.
When prescribing hexamidine to pregnant and lactating breasts, it should be borne in mind that it is similar in action to phenobarbital.
With prolonged use of hexamidine, folic acid deficiency can develop in the body.
The drug is contraindicated in violation of the functions of the liver, kidneys, hematopoietic system.
Form release: tablets of 0.125 and 0.25 g in a package of 50 pieces.
Storage: List B. In a well-closed container.
Abroad under the same name (Hexamidinum, Hexamidine) another drug is released - 4, 4- (hexamethylenedioxy) -dibenzamidine, which is a chemotherapeutic antiprotozoan.