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Description of the medicine: Isadrin (Isadrinum)

ISADRINE (Isadrinum). 1- (3, 4-Dioxyphenyl) -2-isopropylaminoethanol hydrochloride, or N-isopropyl-radrenalaline hydrochloride.

Abroad, it is produced in the form of hydrochloride or sulfate under the names: Isoproterenol, Isuprel, Novodrin, Euspiran, Aleudrin, Aludrin, Antasthmin, Bronchodilatin, Euspiran, Iludrin, Isodrenal, Isonorin, Isoprenalini hydrochloridum, Isoprenaline hydrochloride, Isolrennopropyl chloride, Isoprenaline hydrochloride, Isoprenaln, Isoprenaline, Isoprenaline hydrochloride, Isoprenaline , Neoepinephrine, Norisodrin, Novodrin, etc.

White crystalline powder. Easily soluble in water. Aqueous solutions have a slightly greenish tint.

Isopropyl radradrenaline (isadrine) was obtained in 1938 during the synthesis of adrenaline derivatives.

Chemically, isopropyl radradrenaline belongs to the group of catecholamines and differs in structure from adrenaline in that the methyl radical in the amino group [NH - CH3] is replaced by isopropyl [NH - CH (CH3) 2].

During the pharmacological study of isopropyl radrenaline, it was found that, while retaining some properties of adrenaline, it at the same time differs in effect from the latter. So, it promotes relaxation of the bronchi, but does not cause vasoconstriction and increase peripheral blood pressure; at the same time, like adrenaline, it causes an increase and increase in heart rate.

In this regard, it was suggested that there are different types of adrenoreceptors in the body, with which adrenaline, isopropyl radrenrenaline, and similar compounds can interact predominantly. Finally, the idea of ​​the presence of two main groups of adrenergic receptors (a - and b-adrenergic receptors) was formulated in 1948 (Ahlquist). Subgroups of these receptors were further identified: a 1 - and a 2 -, b 1 - and b 2 -adrenoreceptors.

Isopropyl radradrenaline was recognized as the first representative of a new group of adrenergic substances - β-adrenergic, or β-adrenostimulants.

Following this, new b-adrenostimulants began to appear. A characteristic structural feature of these compounds is the presence of a side chain (alkyl isopropyl, alkyl tert-butyl or another) that brings them closer to the structure of isopropyl radrenaline.

The pharmacological and therapeutic effect of isopropyl radradrenaline (isadrin) is explained by its stimulating effect on β-adrenergic receptors.

The action of isadrine extends simultaneously to the b 1 - and b 2 -adrenoreceptors, therefore, the effect on the bronchi, cardiovascular system and other organs equipped with b-adrenergic receptors is not selective.

Currently, there are a number of new b-adrenostimulants that have a selective effect on b 1 - and b 2 -adrenoreceptors.

Due to the characteristic stimulating effect on β-adrenergic receptors, isadrine has a strong bronchodilating effect, causes an increase and increase in heart contractions, and increases cardiac output.

At the same time, it reduces the total peripheral vascular resistance (due to arterial vasoplegia), lowers blood pressure, and reduces the filling of the ventricles of the heart. The drug increases myocardial oxygen demand.