Medication Description: Anaprilinum
ANAPRILIN (Anaprilinum). (#) -1-Isopropylamino-3- (1-naphthoxy) -2-propanol hydrochloride.
Synonyms: Enderal, Obzidan, Propranolol, Stobetin, Alindol, Angilol, Antarol, Avlocardyl, Bedranol, Betadren, Bricoran, Cardinol, Cardorol, Dederal, Deralin, Dociton, Elanol, Eliblok, Inderal, Inderex, Napril, Diriton, Dociton, Elanol, Eliblok, Inderal, Napral, Napral, Diriton, Diriton, Eralbol, Etirox Propanur, Propral, Propranolol hydrochloride, Pylapron, Sloprolol, Stobetin, Tenomal, Tiperal, etc.
White crystalline powder. Soluble in water and alcohol.
Apariline is b-adrenergic blocker acting on both b 1 - and b 2 -adrenoreceptors (indiscriminate).
By weakening the effect of sympathetic impulses on the b-adrenoreceptors of the heart, anaprilin reduces the strength and frequency of heart contractions, blocks the positive chrono-and inotropic effect of catecholamines. It reduces myocardial contractility and cardiac output. Myocardial need for oxygen is reduced.
Blood pressure under the influence of anaprilina decreases. The tone of the bronchus due to the blockade of b 2 -adrenoreceptors increases.
The drug enhances spontaneous and uterotonic means of uterine contraction. Reduces bleeding during childbirth and in the postoperative period.
Anaprilin is rapidly absorbed by ingestion and is relatively rapidly excreted from the body. The peak concentration in plasma is observed in 1 - 1, 5 h after administration. The drug penetrates the placental barrier.
Anaprilin is used to treat ischemic heart disease, heart rhythm disorders, as well as some forms of hypertension.
In ischemic heart disease, anaprilin reduces the incidence of angina attacks, increases endurance, and limits the need for nitroglycerin. The drug is effective for rest angina, but especially for angina. It is used for resistance to other drugs, in the presence of concomitant arrhythmias, as well as hypertension. As an antiarrhythmic agent, anaprilin is used for sinus and paroxysmal tachycardia, extrasystoles, atrial fibrillation and atrial flutter. The drug is indicated in patients with ventricular exertion after suffering a myocardial infarction.
When sinus tachycardia is usually observed normalization of the rhythm, including in the case of resistance to cardiac glycosides. The drug contributes to the transition of the tachyarrhythmic form of atrial fibrillation to bradyarrhythmic and the disappearance of irregularities and palpitations.
In hypertension, anaprilin is prescribed mainly in the initial stages of the disease. The drug is most effective in young patients (up to 40 years) with hyperdynamic type of blood circulation and with elevated levels of renin. A decrease in blood pressure is accompanied by a decrease in cardiac output due to a decrease in heart rate and a decrease in stroke volume of the heart. Peripheral resistance increases moderately. The drug does not cause orthostatic hypotension. There is evidence of the effectiveness of the drug also in renal hypertension.