Medication Description: Nadolol
NADOLOL *. 2, 3-cis-1, 2, 3, 4-tetrahydro-5- [2-hydroxy-3 (tert-butylamino)] propoxy-2, 3-naphthalene diol.
Synonyms: Korgard, Anabet, Betadol, Corgard, Nadic, Solgol. b -Adrenoblocker of indiscriminate action (blocks b 1 - and b 2 -adrenoreceptors). It has a long duration of action. The half-life is 20 to 24 hours (the half-life of propranolol is 2 to 4 hours, pindolol is 3 to 4 hours, metoprolol is 3 to 5 hours, atenolol is 6 to 9 hours). It has no negative inotropic effect on the myocardium.
The drug has antianginal activity and is used to treat coronary heart disease. Effective also in hypertension (mainly in the early stages).
Assign inside (in pill form), regardless of the meal. Due to the long-lasting effect, it can be used 1 time (sometimes 2 times) per day.
In ischemic heart disease, they take from 40 mg once a day.
After 3-7 days, you can increase the dose to 80-160 mg per day (rarely up to 240 mg). Dose regulate depending on the effect; in the case of excess bradycardia, the dose is reduced. When hypertension is prescribed, 40 80 mg 1 time per day, gradually (at weekly intervals) increase the dose to 240 mg per day (in 1 - 2 doses). You can use diuretics or vasodilators at the same time.
With the use of nadolol, fatigue, insomnia, paresthesia, dry mouth, bradycardia, and gastrointestinal disorders are possible in some cases.
The drug is contraindicated in bronchial asthma and a tendency to bronchiolospasm, sinus bradycardia and heart block II or III degree, cardiogenic shock, with pulmonary hypertension, "congestive" heart disease. Do not prescribe the drug to women during pregnancy and lactation. Caution is needed in renal and hepatic insufficiency, diabetes.
As with other b-blockers, the drug should be discontinued, gradually (within 2 weeks) lowering the dose.
Form release: tablets of 20; 40; 80; 120 and 160 mg (0.02; 0.04; 0.08; 0.12 and 0.16 g) in bottles of 100 and 1000 each.
Storage: List B. At room temperature, in a dark place.
Corzid (Corzide) * is a combination drug containing in one tablet 40 or 80 mg nadolol and 5 mg of the diuretic drug bendroflumethiazide, which is similar in structure and action to dichlothiazide. Applied for the treatment of hypertension.