Medication Description: Labetalol
LABETALOL (Labetalol) *. 5- [1-Oxy-2 - [(1-methyl) -3-phenylpropyl) -amino] ethyl] salicylamide, or 2-hydroxy-5- [1-hydroxy] -2 - [(1-methyl-3- phenyl-propyl) -amino] -ethyl] benzamide (hydrochloride).
Synonyms: Abetol, Albetol, Amipress, Ipolab, Labetol, Labrocol, Lamitol, Opercol, Presolol, Trandate, Trandol
Is b-blocker, simultaneously having a 1 -block-blocking effect.
The combination of b-adrenergic blocking and peripheral vasodilator action provides a reliable antihypertensive effect. The drug does not significantly affect the amount of cardiac output and heart rate.
Labetalol is used to lower blood pressure in hypertension of varying degrees. Unlike conventional b-blockers, it has a fast antihypertensive effect.
Labetalol is rapidly absorbed when taken orally. The half-life of plasma is about 4 hours. Excreted from the body mainly with the urine in the form of inactive metabolites.
Inside, prescribed in the form of tablets (with meals), 0.1 g (100 mg) 2 3 times a day. In severe forms of hypertension, the dose is increased. The average daily dose of 600 - 1000 mg in 2 - 4 doses. For maintenance therapy use 1 tablet (100 mg), 2 times a day.
In hypertensive crises, labetalol is administered intravenously slowly at a dose of 20 mg (2 ml of 1% solution). If necessary, repeat the injection at intervals of 10 minutes. Labetalol is preferably administered as an infusion. To do this, dilute the 1% injection solution in ampoules with an isotonic solution of sodium chloride or glucose to a concentration of 1 mg / ml. Enter at a rate of 2 ml (2 mg) per minute. Usually the required dose is 50 - 200 mg.
Intravenous administrations are performed in the hospital when the patient is lying down (due to a rapid and significant decrease in blood pressure).
When using labetalol, dizziness (as a phenomenon of postural hypotension), headache, nausea, constipation or diarrhea, fatigue, itching,
Labetalol is contraindicated in patients with severe heart failure, atrioventricular block, although in recent years there has been evidence of the beneficial effect of intravenous labetalol on systemic, intracardiac and regional hemodynamics in patients with early myocardial infarction.
The drug usually does not cause bronchiolospasm, but caution should be exercised in patients with bronchial asthma.
Method of production: tablets of 0.1 and 0.2 g (100 and 200 mg), 30 and 100 pieces per pack; 1% solution for injection in 5 ml ampoules (50 mg in the ampoule).
Storage: List B. In the dark spot.