Description of the medicine: Bromocriptine (Bromocriptinum)
BROMOCRIPTIN (Bromocriptinum). 2-Bromo-a-ergocriptine.
Available in the form of mesylate (methanesulfonate).
Synonyms: Parlodel, Bromergon, Bromocriptinum mesilat, Parlodel, Pravidel.
Bromocriptine - a semisynthetic derivative of ergot alkaloids - ergocriptine (see Derivatives of ergot alkaloids). It is a specific agonist of dopamine receptors (mainly type D 2).
The drug actively affects the circulation of dopamine and norepinephrine in the central nervous system, reduces the secretion of serotonin.
In connection with the stimulating effect on the dopamine receptors of the hypothalamus, bromocriptine has a characteristic inhibitory effect on the secretion of hormones of the anterior pituitary, especially prolactin and growth hormone (See Preparations of the anterior pituitary.). Endogenous dopamine is a physiological inhibitor of the secretion of these hormones.
Bromocriptine does not interfere with the synthesis of prolactin. The inhibitory effect on hormone secretion is removed by dopamine receptor blockers (e.g., chlorpromazine).
Bromocriptine (like apomorphine, which is a stimulant of D 2 receptors) has an emetic effect, lowers body temperature, and reduces akinesia caused by reserpine, tetrabenazine, and phenothiazine antipsychotics. The drug has a hypotensive effect associated with an effect on the central nervous system, affects the sympathetic nerve endings and smooth muscles of the vessels. Reduces blood catecholamines.
Unlike ergometrine, methylergometrine and other similar ergot drugs (see), it does not have a "uterine" (oxytocic) effect. On the contrary, it inhibits uterine contractions caused by methylergometrine.
Bromocriptine has been used in obstetric and gynecological practice. In obstetrics, the drug is used to suppress postpartum lactation when it is contraindicated (severe illness of the mother, premature delivery, death of the newborn, etc.). The use of the drug prevents lactation, engorgement of the mammary glands and the development of lactational mastitis, restores ovarian function '.
Prescribe the drug inside (with food) of 2.5 mg (1 tablet) 2 times a day for 10 to 17 days. If necessary, treatment can be continued. Premature withdrawal of the drug can lead to the resumption of lactation.
Along with the cessation of lactation, bromocriptine causes the restoration of the menstrual cycle and promotes pregnancy in women with hyperprolactin amenorrhea.
In gynecological practice with galactorrhea syndrome - amenorrhea that developed after childbirth, in case of dysfunction: ovaries and infertility due to hyperprolactinemia, and for other diseases, 1, 25 mg (1/2 tablet) is prescribed 2-3 times a day, if necessary 2, 5 mg (1 tablet) 2 to 4 times a day. The course of treatment is 3-6 months.
Bromocriptine is also used for galactorrhea induced by the use of antipsychotics (see) and other drugs (contraceptive oral drugs, etc.).