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Medication Description: Cyproheptadine (Cyproheptadinum)

CYPROHEPTADIN (Cyproheptadinum) *. 4- (5-Dibenzo [a, d] cycloheptatrienylidene) -1-methylpiperidine hydrochloride.

Synonyms: Peritol, Adekin, Apetigen, Astonin, Cipractin, Cyprodin, Cyproheptadin hydrochlorid, Istabin, Pariactin, Peritol, Supersan, Vieldrin, Vinorex, etc.

Cyproheptadine has antihistamine activity (it blocks the H 1 receptors), but at the same time it is a strong antiserotonin substance (reduces spasmogenic and other effects caused by serotonin). It also has anticholinergic activity. It has anti-allergic effect, and is especially effective in pruritic dermatoses (possibly due to the antiserotonin action). The drug blocks somatotropin hypersecretion in acromegaly and the secretion of ACTH in Itsenko Cushing's syndrome.

Used for allergic diseases (acute and chronic urticaria, serum sickness, pollinosis, vasomotor rhinitis, contact dermatitis, neurodermatitis, angioedema, allergic reactions to medication, etc.), as well as for migraine (mainly due to the antiserotonin effect) , with loss of appetite of various etiologies (neurogenic anorexia, chronic diseases, etc.).

Due to the fact that histamine and serotonin increase the secretion of pancreatic juice, it has also been proposed to use cyproheptadine in the complex therapy of chronic pancreatitis.

Assign inside: adults 4 mg (1 tablet) 3 - 4 times a day, children in lower doses according to age. At the age of 6 months to 2 years, prescribed with caution in a daily dose of up to 0.4 mg / kg; from 2 to 6 years - up to 6 mg per day (1/2 tablet 3 times a day); from 6 to 14 years old - up to 12 mg per day (1 tablet 3 times a day). Daily doses should not exceed 32 mg in adults, 8 mg in children 2–6 years old, and 12 mg in 6–14 years old.

When using the drug may be drowsiness, dry mouth, in rare cases - anxiety, ataxia, dizziness, nausea, skin rash.

Given the pronounced sedative effect, care should be taken when prescribing the drug to persons whose work is associated with intense physical and mental activity. During treatment with the drug should not drink alcohol.

The drug is contraindicated in pregnancy, glaucoma, urinary retention, predisposition to edema.

Method of production: 4 mg tablets in a package of 20 pieces; syrup (for children) in bottles of 100 ml (in 1 ml of 0.4 mg of the drug).

Storage: List B.