Medication Description: Cimetidine (Cimetidinum)
CYMETHIDIN (Cimetidinum) *.
Synonyms: Belomet, Histak, Histodil, Primamet, Simetidin, Tagamet, Tsimitiget, Tsinamet, Aciloc, Altramet, Belomet, Benomet, Besidin, Cimedal, Cimetar, Cimetiget, Cinamet, Gastromet, Histac, Histodil, Hystac, met, Ne, Pri, ma, met, met, ta, ta, in to, Cinamet, Gastromet, Histac; Surpamet, Tagamet, Tametin, Tamper, Ulcedon, Ulceratil, Ulcimet, Ulcomet, Zagastrol, Zontac, etc.
The main pharmacological effect of cimetidine is the inhibition of gastric juice secretion associated with blockade of H 2 receptors in the stomach wall. It inhibits spontaneous secretion and secretion stimulated by histamine, pentagastrin, caffeine, and also stretching of the stomach, but has little effect on carbacholine hypersecretion, since it does not possess anticholinergic activity. It does not affect the adrenergic receptors, does not have a local anesthetic effect.
The drug reduces pepsin secretion.
Cimetidine is rapidly absorbed from the gastrointestinal tract. Due to its low lipophilicity, it does not penetrate into the central nervous system and does not have a sedative effect.
Cimetidine is used for the treatment of gastric ulcer and duodenal ulcer and in other conditions that require reduction of gastric juice hyperacid, including reflux esophagitis, Zol Linger-Ellison syndrome, etc.
Cimetidine is usually prescribed by mouth (after eating) for adults in a daily dose of 0.8 - 1 g, which is divided into 4 doses: 3 times 0.2 g each and 0.2 or 0.4 g before going to bed. If necessary, increase the daily dose to 1, 6 g. The course of treatment usually lasts 4 to 6 weeks (if necessary up to 8 weeks). At the end of the course of intensive treatment, maintenance therapy is carried out for several months (0.4 g per night or 0.2 g in the morning and 0.2 g in the evening).
Stop taking the drug, gradually reducing the dose. A sudden cessation of intake can lead to a sharp increase in secretion and exacerbation of the disease.
Cimetidine can be used together with antacid drugs, but the antacid should be taken one hour after taking cimetidine, as while taking the absorption of cimetidine is reduced.
Intravenous cimetidine is administered at a dose of 0.2 g (200 mg) at intervals of 4-6 hours. The maximum daily dose is 2 g. With a drip, the dose is 0.1 g (100 mg) per hour for 2 hours; repeat administration every 4 to 6 hours. The maximum infusion rate is 150 mg per hour (or 2 mg / kg per hour). Intravenous administration is performed only in a hospital setting; With rapid intravenous administration, heart rhythm disturbances and a strong decrease in blood pressure are possible.
When using cimetidine, various side effects can occur: diarrhea, muscle pain, allergic reactions (skin rashes), headache, dizziness, depression. Changes in biochemical parameters (the value of transaminases, etc.) may be observed. With prolonged use of high doses of the drug, gynecomastia may develop, which is associated with the ability of the drug to stimulate the secretion of prolactin. There is also evidence that cimetidine inhibits the production of intrinsic factor and the absorbability of vitamin B 12, and that it may have an anti-androgenic effect.