Description medicines: cimetidine (Cimetidinum)
Cimetidine (Cimetidinum) *.
Synonyms: Belomet, Gistak, Gistodil, Primamet, Cimetidine, Tagamet, Tsimitiget, Tsinamet, Aciloc, Altramet, Belomet, Benomet , Besidin, Cimedal, Cimetar, Cimetiget, Cinamet, Gastromet, Histac, Histodil, Hystac, Neutronorm, Primamet, Simetidin, Surpamet, Tagamet, Tametin, Tamper, Ulcedon, Ulceratil, Ulcimet, Ulcomet, Zagastrol, Zontac and others.
The main pharmacological effect is the inhibition of cimetidine s secretion of gastric juice, associated with the blockade of H2 receptors of the stomach wall. It inhibits the spontaneous secretion and secretion stimulated by histamine, pentagastrin, caffeine, and the stretching of the stomach, but has little effect on karbaholinovuyu hypersecretion as anticholinergic lacks ak ciency. It has no effect on adrenergic receptors, it does not have a local anesthetic action.
The drug decreases the release of pepsin.
Cimetidine is rapidly absorbed from the gastrointestinal tract. Due to the low lipophilicity does not penetrate the central nervous system and has no sedative effect you.
Apply cimetidine for the treatment of gastric ulcer and duodenal ulcer dvenadtsa and other conditions requiring reduction giperatsid of gastric juice, including the reflux esophagitis, Zol Linger syndrome - Ellison et al.
Assign cimetidine usually inside (after eating) adults in a daily dose of 0.8 - 1 g, which is divided into 4 stages: 3 x 0.2 g and 0.2 g or 0.4 before bedtime. If necessary, increase the daily dose of 1, 6, the course of treatment usually lasts 4 - 6 weeks (if necessary to 8 weeks). After the course of treatment carried out intensive supportive therapy for several months (0.4 g at night or in the morning and evening 0.2g 0.2g).
Stop taking the drug, gradually reducing the dose. Sudden discontinuation may lead to a sharp increase in secretion and exacerbate the disease.
Cimetidine may be used together with antacids, antacid but must be taken one hour after administration of cimetidine, since the simultaneous administration of cimetidine absorption decreases.
Cimetidine intravenously administered at a dose of 0.2 grams (200 mg) at intervals of 4 - 6 hours maximum daily dose is 2 grams When a drip dose is 0.1 g (100 mg) per hour for 2 hours.; administration repeated every 4 - 6 hours The maximum infusion rate -. 150 mg per hour (or 2 mg / kg per hour). Intravenous administration produced only in a hospital environment; With rapid intravenous possible cardiac arrhythmia and severe decrease in blood pressure.
In the application of cimetidine may experience different side effects: diarrhea, muscle pain, allergic reactions (skin rash), headache, dizziness, depression. There may be changes in biochemical parameters (transaminases value, etc..). With prolonged use of high doses of the drug may develop gynecomastia, which is associated with the ability of the drug to stimulate the secretion of prolactin. There is also evidence that cimetidine inhibits production of intrinsic factor and vitamin B12 absorption, and that it may have anti-androgenic effect.