Medication Description: Acediprol (Acediprolum)
Sodium salt of 2-propylvaleric acid:
Synonyms: Apilepsin, Depakine, Konvuleks, Apilepsin, Convulex, Convulsovin, Depaken, Depakin, Deprakine, Diplexil, Epikine, Epilim, Everiden, Leptilan, Orfilept, Orfiril, Propymal, Valpakine, Valpropine, Valprpine, Sharpin, Orpilept
Acetiprol is a white crystalline powder, easily soluble in water and alcohol.
It is a broad-spectrum antiepileptic remedy. The drug is easily absorbed by ingestion. The peak concentration in plasma is observed after 2 hours. The half-life is approximately 8 hours. It is mainly excreted in urine as conjugates or oxidation products.
Applied in adults and children with different types of epilepsy: in various forms of generalized seizures - small (absans), large (convulsive) and polymorphic; with focal seizures (motor, psychomotor, etc.). The drug is most effective for absansa and temporal pseudoabsansah.
Take acediprol inside during or immediately after a meal. Begin by taking small doses, gradually increasing them within 1 to 2 weeks until a therapeutic effect is achieved; then select an individual maintenance dose.
The daily dose for adults at the beginning of treatment is 0.3–0.6 g (1–2 tablets), then it is gradually increased to 0.9–1.5 g. A single dose of 0.3–0.45 g. The highest daily dose 2, 4 g
The dose for children is selected individually depending on the age, severity of the disease, therapeutic effect. Typically, the daily dose for children is 20–50 mg per 1 kg of body weight, the highest daily dose is 60 mg / kg. Begin treatment with 15 mg / kg, then increase the dose weekly by 5-10 mg / kg to achieve the desired effect. The daily dose is divided into 2 - 3 doses. It is convenient for children to prescribe the drug in the form of a liquid dosage form - 5 ml of acediprol syrup (Sirupus Acediproli 5%) containing 50 mg of the drug in 1 ml. The required amount of syrup is measured with a dosing spoon with graduations 2, 5 and 5 ml.
Acetiprol can be used alone or in combination with other antiepileptic drugs.
For minor forms of epilepsy, it is usually limited to the use of acediprol alone.
Acetiprol has not only anticonvulsant (antiepileptic) effect. It also improves the mental state and mood of the sick. It has been shown that sodium valproate has a tranquilizing component, and, unlike other tranquilizers, it does not have a somnolent, sedative, and muscle relaxant function, reducing the state of fear.
According to experimental data, the drug has antiarrhythmic activity, caused, apparently, by the activation of the central inhibitory stress-limiting GABAergic system, as well as by direct cardiotropic action.
Possible side effects: nausea, vomiting, diarrhea, stomach pain, anorexia or increased appetite, drowsiness, allergic skin reactions.