Description of the medicine: Propazinum (Propazinum)
PROPAZIN (Propazinum). 10- (3-Dimethylaminopropyl) -phenothiazine hydrochloride.
Synonyms: Ampazine, Amprazin, Centractil, Frenyl, Neuroleptil, Prazine, Promazine, Promazini hydrochloridum, Promazine hydrochloride, Promazinon, Promazinum, Protactyl, Sediston, Sinophenin, Sparine, Talofen, Verophen, etc.
Crystalline powder, white or white with a slight yellowish tint. Very soluble in water. Hygroscopic. In the light, the powder and its solutions acquire a bluish-green color.
In structure, propazine differs from chlorpromazine in the absence of a chlorine atom in position 2 of the phenothiazine core.
By pharmacological properties it is close to chlorpromazine. Like chlorpromazine, it causes a sedative effect, reduces locomotor activity, increases the duration and intensity of hypnotics, narcotic and local anesthetics; possesses antiemetic and hypothermic properties. According to the sedative effect, propazine is inferior to chlorpromazine. The peripheral cholinergic and adrenolytic effects of both drugs are not significantly different; the antihistamine effect is more pronounced in propazine.
Propazine is slightly less toxic than chlorpromazine; has a slightly less local irritant effect and less likely to cause allergic reactions.
In psychiatric practice, propazine is used according to the same indications as chlorpromazine, especially in cases with a milder course of the disease, for maintenance therapy, as well as in debilitated patients and seniors, in children. It is inferior to chlorpromazine by the force of action on arousal and by antipsychotic effect. However, less pronounced side effects, lack of drowsiness, depression, a feeling of heaviness in the head allow you to widely use this drug.
Propazine is administered orally, intramuscularly and intravenously. Inside appoint in the form of dragees or tablets on 0,025 - 0,05 - 0,1 g 2 - 4 times a day after food. Intramuscularly administered at 0.05 - 0.1 - 0.15 g 2 - 3 times a day, and the required amount of ampouled (2, 5%) solution of propazine is diluted in 5 ml of 0.25 - 0.5% solution of novocaine or isotonic sodium chloride solution. 1–2 ml of a 2.5% propazine solution diluted in 10–20 ml of a 5% glucose solution or isotonic sodium chloride solution is administered intravenously.
If necessary, the dose of propazine is gradually increased to 0.5 - 1 g per day. For maintenance therapy, 0.05 - 0.15 g is prescribed 1 to 2 times a day.
Higher doses for adults inside: single 0.25 g, daily 2 g; intramuscularly: single 0.15 g, daily 1, 2 g.
In neurological, therapeutic, obstetric-gynecological, dermatological practice, propazine can be used instead of chlorpromazine.
Propazine can be used in combination with other neurotropic drugs, including as a part of lytic mixtures (for example, according to the prescription: propazine 2, 5% solution 1 - 2 ml, diphenhydramine 2% solution 2 ml, promedol 2% solution 1 - 2 ml) , as well as with sleeping pills.
Possible complications are the same as with the use of chlorpromazine, but are slightly less pronounced and occur less frequently.
Method of release: coated tablets and tablets of 0.025 and 0.05 g, coated; 2, 5% solution in ampoules of 2 ml.