Medication Description: Propazin (Propazinum)
PROPAZIN (Propazinum). 10- (3-Dimethylaminopropyl) -phenothiazine hydrochloride.
Synonyms: Ampazine, Amprazin, Centractil, Frenyl, Neuroleptil, Prazine, Promazine, Promazini hydrochloridum, Promazine hydrochloride, Promazinon, Promazinum, Protactyl, Sediston, Sinophenin, Sparine, Talofen, Verophen, etc.
White or white with a faint yellowish sheen crystalline powder. Very easily soluble in water. Hygroscopic. In the light, the powder and its solutions acquire a bluish-green color.
The structure of propazine differs from aminazine in the absence of a chlorine atom in position 2 of the phenothiazine nucleus.
On pharmacological properties close to chlorpromazine. Like aminazin causes sedation, reduces motor activity, increases the duration and intensity of the action of hypnotic, narcotic and local anesthetics; possesses antiemetic and hypothermic properties. By sedative effect, propazin is inferior to aminazin. The peripheral cholino- and adrenolytic effects of both drugs are not significantly different; antihistamine effect is more pronounced in propazine.
Propazin is somewhat less toxic than aminazin; has a slightly less local irritant effect and less likely to cause allergic reactions.
In psychiatric practice, propazin is used according to the same indications as aminazine, especially in cases with a milder course of the disease, for maintenance therapy, as well as in debilitated patients and seniors, in children. It is inferior to chlorpromazine by its strength of action on arousal and on its antipsychotic effect. However, less pronounced side effects, lack of drowsiness, depression, feeling of heaviness in the head allow using this drug widely.
Apply propazin inside, intramuscularly and intravenously. The inside is prescribed in the form of dragees or tablets of 0.025 - 0.05 - 0.1 g 2-4 times a day after meals. Intramuscularly injected at 0.05 - 0.1 - 0.15 g 2 - 3 times a day, and the required amount of ampu lated (2, 5%) solution of propazine is diluted in 5 ml of 0.25 - 0.5% solution of novocaine or isotonic sodium chloride solution. Intravenously injected in 1 - 2 ml of a 2, 5% solution of propazin, diluted in 10 - 20 ml of 5% glucose solution or isotonic sodium chloride solution.
If necessary, the dose of propazin gradually increased to 0.5 - 1 g per day. For maintenance therapy prescribed in 0.05 - 0.15 g 1 - 2 times a day.
Higher doses for adults inside: single 0.25 g daily 2 g; intramuscularly: single 0.15 g daily 1, 2 g
In neurological, therapeutic, obstetric-gynecological, dermatological practice, propazine can be used instead of aminazine.
Propazin can be used in combination with other neurotropic drugs, including in the composition of lytic mixtures (for example, according to the recipe: propazin 2, 5% solution 1 - 2 ml, dimedrol 2% solution 2 ml, promedola 2% solution 1 - 2 ml) , as well as with sleeping pills.
Possible complications are the same as when using chlorpromazine, but somewhat less pronounced and occur less frequently.
Forms of release: coated tablets and tablets of 0.025 and 0.05 g, coated; 2, 5% solution in ampoules of 2 ml.