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Medication Description: Meterazine (Metherazinum)

Metherasin (Metherazinum). 2-Chloro-10- [3- (1-methylpiperazinyl-4) -propyl] -phenothiazine dimaleate.

Synonyms: Chlormeprazine, Chlorperazin, Compazine, Dicopal, Nipodal, Novamin, Prochlorpemazine, Prochlorperazini maleas, Prochlorperazine maleate, Stemetil, Temetil, etc.

White with a slightly yellowish tint or light cream crystalline powder. Practically insoluble in water, very slightly soluble in alcohol. The light turns red.

The structure is close to aminazin; characterized by the presence of a piperazine nucleus in the side chain.

Like other piperazine derivatives of fenothiazine (ethacterazine, triftazin, etc.), merazine weakens psychotic symptoms — delusions and hallucinations; however, it has an activating (stimulating, energizing) effect.

Applied for the treatment of patients with schizophrenia, involutional and other psychoses with a predominance in the clinical picture of lethargy, apathy, asthenic phenomena, subcompetitive and stuporous states.

Assign inside after eating, ranging from 0,0125 - 0,025 g (12, 5 - 25 mg) per day and gradually increasing the dose by 12, 5 - 25 mg per day to a daily dose of 0.15 - 0.3 g (sometimes up to 0.4 g). The course duration is 2 - 3 months or more, after which the dose is gradually reduced, individually selecting the supporting dose.

The use of Metarazine in relatively large doses can cause exacerbation of psychosis, insomnia, tachycardia. Large doses often provoke the development of spastic pyramidal disorders, dyskinesias. With prolonged treatment, granulocytopenia may develop.

Product form: tablets of 0.005 g (5 mg) and 0.025 g (25 mg), coated, in glass jars of 50,100 and 250 pieces.

Storage: List B. In the dark spot.