Description of the medicine: Bromhexine (Bromhexinum)
N- (2-amino-3, 5-dibromobenzyl) -N-methylcyclohexylamine hydrochloride.
Synonyms: Bisolvon, Solvin, Phlegamine, Bisolvon, Brexol, Brodisol,
Brombenzonium, Bromhexinchlorid, Broncokin, Flegamin, Lisomucin, Mucovin,
Mugocil, Solvin et al.
White crystalline powder. Slightly soluble in water and alcohol.
The drug has a mucolytic (secretolytic) and expectorant effect. The mucolytic effect is associated with depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. According to modern concepts, one of the important features of the action of bromhexine is its ability to stimulate the formation of surfactant.
The drug has a weak antitussive effect.
Bromhexine is used as an expectorant for acute and chronic bronchitis of various etiologies, including complicated by bronchiectasis, as well as for the infectious-allergic form of bronchial asthma, pulmonary tuberculosis, acute and chronic pneumonia. The drug can be used for sanitation of the bronchial tree in the preoperative period, as well as to prevent the accumulation of thick viscous sputum in the bronchus after surgery. It is also prescribed to accelerate the release of contrast medium after bronchography.
Bromhexine is taken orally (regardless of food intake) in the form of a current tablet. Doses for adults - 0.016 g (16 mg = 2 tablets of 0.008 mg) 3 4 times a day; for children from 3 to 4 years old - at 0.002 g (2 mg), from 5 to 14 years at 0.004 g (4 mg) 3 times a day; for children under 3 years of age, the drug is not prescribed.
The effect of the drug usually begins to appear 24 to 48 hours after the start of treatment. The course of treatment is from 4 days to 4 weeks.
If necessary, Bromhexine is prescribed simultaneously with antibacterial, bronchodilating, cardiac and other agents.
The drug is usually well tolerated. In some cases, allergic reactions (skin rash, rhinitis, etc.) are possible. With prolonged use, dyspeptic disorders are possible. Side effects occur when the drug is discontinued.
Release form: tablets for adults of 0.008 g (8 mg) (pink) in a package of 20 pieces and tablets for children of 0.004 g (4 mg) in a package of 10 and 50 pieces.
Storage: List B. In a dry, dark place.
Bromhexine is also produced abroad in the form of 4 mg tablets (green) in a package of 50 pieces and in the form of an elixir (4 mg in 5 ml).
Under the name Flegamin, a syrup is produced in Poland containing 0.08 g (80 mg) of bromhexine, menthol, eucalyptus and peppermint oils, distilled water (up to 100 ml) in 100 ml.
Release form: in bottles of orange glass on 120 ml.