Medication Description: Bromhexin (Bromhexinum)
N- (2-Amino-3, 5-dibromobenzyl) -N-methylcyclohexylamine hydrochloride.
Synonyms: Bisolvon, Solvin, Flegamin, Bisolvon, Brexol, Brodisol,
Brombenzonium, Bromhexinchlorid, Broncokin, Flegamin, Lisomucin, Mucovin,
Mugocil, Solvin and others.
White crystalline powder. It is soluble in water and alcohol.
The drug has mucolytic (secretolytic) and expectorant effect. The mucolytic effect is associated with the depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. According to modern concepts, one of the important features of the action of bromhexine is its ability to stimulate the formation of surfactant.
The drug has a weak antitussive effect.
Bromhexine is used as an expectorant for acute and chronic bronchitis of various etiologies, including those complicated by bronchoectases and also for infectious-allergic bronchial asthma, pulmonary tuberculosis, acute and chronic pneumonia. The drug can be used to rehabilitate the bronchial tree in the preoperative period, as well as to prevent the accumulation of thick viscous sputum in the bronchus after surgery. Assign also to accelerate the release of a contrast agent after bronchography.
Bromhexine is taken orally (regardless of the meal) in the form of tablets. Doses for adults - by 0.016 g (16 mg = 2 tablets of 0.008 mg) 3 4 times a day; for children from 3 to 4 years old - 0.002 g (2 mg), from 5 to 14 years old, 0.004 g (4 mg) 3 times a day; children under 3 years old are not prescribed the drug.
The effect of the drug begins to manifest itself usually within 24 to 48 hours after the start of treatment. The course of treatment is from 4 days to 4 weeks.
If necessary, Bromhexine is prescribed simultaneously with antibacterial, bronchodilator, cardiac and other agents.
The drug is usually well tolerated. In some cases, allergic reactions are possible (skin rash, rhinitis, etc.). With long-term admission dyspeptic disorders are possible. Side effects disappear when drug is withdrawn.
Product form: adult tablets of 0.008 g (8 mg) (pink) in a package of 20 pieces and tablets for children of 0.004 g (4 mg) in a package of 10 and 50 pieces.
Storage: List B. In a dry, dark place.
Abroad, Bromhexine is also available in the form of dragees (green) 4 mg in a package of 50 pieces and in the form of an elixir (4 mg in 5 ml).
Under the name "Flegamin" (Flegamin) a syrup is produced in Poland, containing 100 ml of 0.08 g (80 mg) of bromhexine, menthol, eucalyptus and mint oils, distilled water (up to 100 ml).
Product: in orange glass bottles of 120 ml.