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Medication Description: Ambroxol (Ambroxolum)

AMBROXOL (Ambroxolum) *. trans-4 - [(2-amino-3, 5-dibromobenzyl) amino] cyclohexanol hydrochloride.

Synonyms: Lasolvan, Lasolvan, Ambrolitic, Bronchopront, Fluixol,

Lindoxyl, Mucofar, Mucosan, Mucosolvon, Mucovent, Secretil, Viscomcil, etc.

A white crystalline powder; odorless, slightly bitter taste.

The chemical structure is close to bromhexine. It differs from the latter by the absence of a methyl group at the nitrogen atom of the side chain and the presence of hydroxyl in the para-position of the hexyl core.

In terms of pharmacological properties and mechanism of action, ambroxil is not significantly different from bromhexine. Both are mucolytic agents that stimulate the formation of surfactant, normalize the changed bronchopulmonary secretion, improve the rheological parameters of muscle tissue, reduce its viscosity and adhesive properties, facilitate its removal from the bronchi.

Ambroxol (lasolvan) attracts much attention due to the general interest in the means of stimulating the formation of surfactant.

Indications for use are basically the same as for Bromhexine.

Ambroxol (lasolvan) is not significantly different from bromhexine in terms of its effect on surfactant products and mucociliary transport. There are indications that Ambroxol can also be used to stimulate the formation of surfactant in premature babies and newborns with the syndrome of respiratory failure.

Adults Ambroxol (Lasolvan) is prescribed by mouth for 1 tablet (30 mg) 3 times a day; with long-term treatment - 1 tablet 2 times a day. Take after meals with a small amount of water.

Children are recommended to give as a syrup (15 mg of ambroxol in 5 ml) in the following doses: up to 2 years - 2, 5 ml 2 times a day, from 2 to 5 years - 2, 5 ml 3 times a day, older than 5 years - 5 ml 2 - 3 times a day. In the first 2 - 3 days of treatment, the dose can be doubled. Adults appoint a syrup in the first 2 - 3 days, 10 ml 3 times a day, then 5 ml 3 times a day.

Ambroxol (Lasolvan) can also be used as an inhalation solution (15 mg in 2 ml): in adults and children over 5 years old, 1 to 2 inhalations per day, 2 to 3 ml per day; in children under 5 years old, 1 to 2 inhalations per day, 2 ml each.

The drug can be administered intramuscularly or intravenously. Adults are given 2 to 3 ampoules (15 mg per ampoule) 2 to 3 times a day; children under 2 years old and 1/2 ampoules 2 times a day; from 2 to 5 years - 1/2 ampoules 3 times a day, over 5 years old - 1 ampoule 2 - 3 times a day. In the case of respiratory failure syndrome, it is administered at the rate of 10 mg / kg per day (in 3 - 4 doses).

The drug is usually well tolerated. In some cases, nausea and vomiting are possible.

Do not prescribe Ambroxol in the first 3 months of pregnancy.

Method of production: tablets of 30 mg in a package of 50 pieces; ampoules containing 15 mg of the drug; syrup containing 15 mg of the drug in 5 ml, in a package of 100 ml; solution for inhalation, containing 15 mg of the drug in 2 ml, in a package of 100 ml.