Description of the medicine: Isosorbide mononitrate (Isosorbide mononitrate)
ISOSORBIDE MONONITRATE (Isosorbide mononitrate). 1, 4, 3, 6-Dianhydro-D-sorbitol-5-mononitrate.
Synonyms: Monisid, Monisid, Bonivix, Corangin, Duramonitat, Elantan, Isomonat, Medocor, Monit, Mononit, Monoclair, Monoket, Monizol, Mono-Mack, Olicard, etc.
Isosorbide mononitrate is the main metabolite of isosorbide dinitrate (nitrosorbide). Based on current data, in order to exert a vasodilatory effect, it should be further metabolized to form NO groups.
By the nature of the action, isosorbide mononitrate is close to nitrosorbide. However, in comparison with nitrosorbide, it has a higher bioavailability and has a longer half-life (up to 6 hours) after oral and intravenous administration.
The antianginal effect occurs 30 to 45 minutes after oral administration and lasts up to 8 to 10 hours, and with intravenous administration, immediately after the start of the infusion.
Indications for use inside are the same as for nitrosorbide. With severe angina pectoris, anginal status, hypertension in the pulmonary circle of blood circulation, administered intravenously. In acute left ventricular failure, nitroglycerin has a faster and more direct effect.
Inside, with ischemic heart disease in the complex therapy of heart failure, 0.02 g (20 mg) are prescribed 2–3 times a day; in severe conditions - 0.04 g (40 mg) 2-3 times a day.
From 1 to 5 ampoules per day are injected into a vein; administered slowly or drip at the rate of 5 - 15 mcg / kg per minute.
Possible side effects and contraindications are the same as for other organic nitrates.
Method of release: tablets of 0.02 g (20 mg) in a package of 50 pieces, tablets of 0.04 g (40 mg) in a package of 20 pieces; 1% solution in ampoules of 1 ml (10 mg) in a package of 50 ampoules.
Storage: List B. At room temperature, in a dry, dark place.