Description of the medicine: Thioridazinum (Thioridazinum)
Thioridazine (Thioridazinum). 2-Methylthio-10- [2- (1-methyl-2-piperidyl) ethyl] phenothiazine hydrochloride.
Synonyms: Melleril, Sonapax, Tioril, Mallorol, Malloryl, Mellaril, Melleril, Sonapax, Thioridazine hydrochloride, Thioril.
According to antipsychotic activity, thioridazine is inferior to chlorpromazine, levomepromazine. Antipsychotic effect is combined with a calming effect without marked inhibition, lethargy, emotional indifference. It has a moderate stimulating effect. Along with the antipsychotic, a moderate timoleptic (antidepressant) effect is noted. It has almost no cataleptic effect and is much less likely than other phenothiazine preparations to cause extrapyramidal disorders.
Most effective in mental and emotional disorders, accompanied by fear, tension, agitation.
In psychiatric practice, they are used for acute and subacute schizophrenia, organic psychoses, psychomotor agitation, manic-depressive states, neurosis and other diseases. Assign in mild cases of the disease at 0.05 - 0.1 g - (50 - 100 mg) per day; in more severe cases, 0.15-0.6 g per day.
In outpatient practice, thioridazine is used at a dose of 40-100 mg per day to treat borderline conditions. At small doses, the stimulating and antidepressant effect is more pronounced, with an increase in the dose, the sedative effect increases.
In case of neurasthenia, increased irritability, anxiety, neurogenic functional gastrointestinal and cardiovascular disorders, chronic sleep disorders, appoint 0.005-0.01-0.025 g 2-3 times a day, and with premenstrual nervous tension and menopausal disorders - 0.025 g 1 - 2 times a day.
Children with psychopathic behavior, increased irritability, anxiety, nightly fears and others are prescribed 0.005-0.01 g (5-10 mg) 2 to 3 times a day; the daily dose for children of preschool and early school age is 10-30 mg, and for older children up to 40-60 mg.
Contraindications: coma, allergic reactions and changes in the blood picture when using other drugs. There are indications that with prolonged use of thioridazine, the development of toxic retinopathy is possible.
Forms of release: tablets containing 0.01; 0.025 and 0.1 g of the drug. For children's practice - 0.2% suspension (2 mg in 1 ml).
Storage: List B.