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Description of the medicine: Dibazol (Dibazolum)

DIBAZOL (Dibazolum). 2-Benzylbenzimidazole hydrochloride.

Synonyms: Bendazol, Bendazoli hydrochloridum, Bendazole hydrochloride, Tromasedan.

White or white with a slightly grayish or yellowish tint, crystalline powder of a bitter-salty taste.

It is soluble in water, it is easily in alcohol. Hygroscopic. Solutions (pH 2, 8 - 3, 5) are sterilized at + 100 C for 30 minutes.

It has a vasodilating, antispasmodic and hypotensive effect, as well as a stimulating effect on the function of the spinal cord.

Dibazole has elements of similarity in structure and action with the drug levamisole (see) and has moderate immunostimulating activity.

It is used for spasms of blood vessels (exacerbation of hypertension, hypertensive crises) and smooth muscles of internal organs (peptic ulcer, spasm of the pylorus and intestines, etc.), as well as for the treatment of nervous diseases, mainly residual effects of poliomyelitis, peripheral facial paralysis nerve, etc.

According to experimental data, dibazole lowers tone and causes vasodilation of the brain, however, with clinical use, this effect, controlled by rheoencephalography, is short-lived.

Dibazole is prescribed intravenously, intramuscularly and orally.

To stop hypertensive crises, 3-4 ml of a 1% solution or 6-8 ml of a 0.5% solution (0.03 0.04 g) are administered intravenously or intramuscularly. With exacerbation of hypertension with a significant increase in blood pressure, intramuscular administration of 2–3 ml of a 1% solution or 4–6 ml of a 0.5% solution (0.02–0.03 g) 2–3 times a day is indicated. The course of treatment is 8-14 days. At the same time with dibazole, other antihypertensive drugs (reserpine, hypothiazide, etc.) can be used.

Inside take 0.02 - 0.05 g 2 - 3 times a day, usually for 3 to 4 weeks or shorter courses.

In the treatment of nervous diseases, dibazole is prescribed from 5 to 10 times, at a dose of 0.005 g (adults), once a day or every other day. After 3 to 4 weeks, the course of treatment is repeated. The subsequent courses are carried out with an interval of 1 - 2 months.

Higher doses for adults inside: single 0.05 g, daily 0.15 g.

Children are prescribed (in the treatment of diseases of the nervous system) in the following doses: up to 1 year old - 0.001 g, 1-3 years old - 0.002 g, 4-8 years old - 0.003 g, 9-12 years old - 0.004 g, over 12 years old - 0.005 g If necessary, repeat the treatment after 3 to 4 weeks.

Dibazole is taken internally 2 hours before meals or 2 hours after meals.

Dibazole is usually well tolerated. It is known that it is not advisable to prescribe the drug for a long time as an antihypertensive agent in elderly patients, since the antihypertensive effect is associated with a decrease in cardiac output and an electrocardiogram may worsen.

Release form: tablets on 0,02; 0.002; 0.003 and 0.004 g; 0.5% or 1% solution in ampoules of 1; 2 and 5 ml.

Storage: List B.

Dibazole is also part of a number of combination tablets: Papazol (see Papaverine), Amazole (see Amidopyrine), Andipal (see Analgin), Theodibaverine (see Theobromine).

There are also ready-made tablets containing dibazole and phenobarbital at 0.025 g; dibazole 0.03 g, theobromine 0.25 g and platifillin hydrotartrate 0.003 g.