Description of medicine: Calcium dobesilate (Calcii dobesilas)
CALCIUM DOBESILATE (Calcii dobesilas). 2, 5-Dioxybenzenesulfonate calcium dihydrate.
Synonyms: Doxium, Dobesifar, Dobesilat-calcium, Etruval, Romiven, Stifarol, Tricatine, etc.
Crystal powder, white or white with a creamy or pinkish tint. Easily soluble in water. Hygroscopic.
In structure and action, it is close to etamzilate; it has a slightly more pronounced normalizing effect on vascular permeability, increases capillary resistance, improves microcirculation and drainage function of lymphatic vessels, slightly reduces platelet aggregation, and reduces blood viscosity. It has some antihemorrhagic effect.
The drug is slowly absorbed from the gastrointestinal tract; the maximum concentration in the blood after ingestion is observed after 5 - 6 hours. As an ionized compound, it practically does not penetrate the blood-brain barrier. It is excreted mainly by the kidneys within 24 hours.
The action of the drug is associated to a certain extent with an increase in platelet activity, a decrease in the activity of plasma kinins (bradykinin; see Parmidin), as well as with a direct effect on the vascular endothelium.
Calcium dobesilate is used for various diseases accompanied by impaired vascular permeability and microcirculatory disorders, including diabetic retinopathy and other angiopathies, microangiopathy in hemorrhagic and post-thrombotic syndrome, varicose veins and prevaricose conditions with symptoms of tissue edema, superficial fibrosis and phlebitis .
Take orally during or after meals, 1 tablet (0.25 g) 3-4 times a day. The course of treatment is from 3 to 4 weeks to several months, depending on the effect. The treatment courses can be repeated if necessary.
When taking calcium dobesilate dyspeptic symptoms, allergic skin reactions are possible. In these cases, if necessary, reduce the dose or stop taking the drug.
Contraindicated in pregnancy.
Release form: tablets of 0.25 g in a package of 50 and 100 pieces in cans of protective glass.
Storage: List B. In a dry, dark place.