Medication Description: Calcium dobesilas (Calcii dobesilas)
CALCIUM DOBEZILAT (Calcii dobesilas). 2, 5-Dioxy-benzenesulfonate calcium dihydrate.
Synonyms: Doxium, Dobesifar, Dobesilat-calcium, Etruval, Romiven, Stifarol, Tricatine, etc.
White or white with a creamy or pinkish tinge crystalline powder. Easily soluble in water. Hygroscopic.
In structure and action close to etamzilat; has a slightly more pronounced normalizing effect on vascular permeability, increases capillary resistance, improves microcirculation and drainage function of lymphatic vessels, slightly reduces platelet aggregation, reduces blood viscosity. It has some antihemorrhagic effect.
The drug is slowly absorbed from the gastrointestinal tract; the maximum concentration in the blood after oral administration is observed after 5 to 6 hours. As an ionized compound, it practically does not penetrate the blood-brain barrier. Mainly excreted by the kidneys within 24 hours.
The effect of the drug is associated to a certain extent with an increase in platelet activity, a decrease in plasma kinin activity (bradykinin; see Parmidin), as well as a direct effect on the vascular endothelium.
Apply calcium dobesilate at various diseases involving disorders of vascular permeability and disorders of the microcirculation, including diabetic retinopathy and other angiopathy, microangiopathy in hemorrhagic and post-thrombotic syndrome, varicose veins and prevarikoznyh states with signs of tissue edema, superficial phlebitis, venous ulcers, etc. .
Is taken orally during or after a meal, 1 tablet (0.25 g) 3 - 4 times a day. The course of treatment from 3 - 4 weeks to several months, depending on the effect. Treatment can be repeated if necessary.
When taking dobesilate calcium, dyspeptic symptoms and allergic skin reactions are possible. In these cases, if necessary, reduce the dose or stop taking the drug.
Contraindicated in pregnancy.
Product form: tablets of 0.25 g in a package of 50 and 100 pieces in cans of light-protective glass.
Storage: List B. In a dry, dark place.