Medication Description: Ethacrynic Acid (Acidum etacrynicum)
ETAKRINOVA ACID (Acidum etacrynicum). 2, 3-Dichloro-4- (2-methylene-1-oxobutyl) phenoxyacetic acid, or 4- (2-ethyl-acryloyl) -2, 3-dichlorophenoxyacetic acid.
Synonyms: Uregit, Crinuril, Ecrinex, Edecril, Edecrin, Endecril, Etacrynic acid, Hydromedin, Otacril, Uregit.
It is a strong diuretic. The mechanism of action is close to furosemide, but does not increase bicarbonate excretion and does not significantly violate the electrolyte composition of the blood.
Acts fast; diuresis begins after 30–60 minutes, reaches a maximum after 2 hours, continues after a single dose of 6–9 hours.
Prescribed for edema in patients with circulatory failure; in case of edema of renal origin, especially resistant to the action of other diuretics; with acute pulmonary edema; swelling of the brain.
It has a moderate antihypertensive effect; with hypertension can be used in combination with antihypertensive drugs.
Assign inside, from 0.05 g (50 mg), increasing, if necessary, the daily dose of the drug to 0.1 - 0.2 g. Usually take the entire dose of the drug in the morning (after meals).
The diuretic effect is often more pronounced if the drug is not taken daily, but with a break of 1 - 2 days.
Intravenous (0.05 g) is administered in cases where rapid effect is required (see Furosemide).
With prolonged use of the drug can be observed hypokalemia and hypochloremic alkalosis. The simultaneous use of potassium-sparing diuretics enhances the diuretic effect of the drug and reduces hypokalemia and alkalosis.
Ethacrynic acid is worse tolerated than furosemide, especially in patients with renal insufficiency.
With the use of the drug may be dizziness, weakness, dyspepsia, diarrhea.
Treatment should be carried out against the background of a diet rich in potassium, and, if necessary, prescribe potassium preparations.
Contraindications are the same as for dichlothiazide. The drug is not recommended for anuria and pregnant. Young children prescribed only in exceptional cases (with resistance to other diuretics). With cirrhosis of the liver, the use of the drug requires careful medical supervision.
Method of production: tablets of 0.05 g in a package of 20 pieces; in ampoules containing 0.05 g of sodium salt of ethacrynic acid, which is dissolved with isotonic sodium chloride or glucose solution.
Storage: List B.