Description of the medicine: Ethacrine acid (Acidum etacrynicum)
ETHACRIC ACID (Acidum etacrynicum). 2, 3-Dichloro-4- (2-methylene-1-oxobutyl) phenoxyacetic acid, or 4- (2-ethyl-acryloyl) -2, 3-dichlorophenoxyacetic acid.
Synonyms: Uregit, Crinuril, Ecrinex, Edecril, Edecrin, Endecril, Etacrynic acid, Hydromedin, Otacril, Uregit.
It is a strong diuretic. According to the mechanism of action, it is close to furosemide, but does not increase the release of bicarbonate and does not significantly violate the electrolyte composition of the blood.
It acts quickly; diuresis begins after 30-60 minutes, reaches a maximum after 2 hours, continues after a single dose of 6-9 hours.
Assign for edema in patients with circulatory failure; with edema of renal origin, especially resistant to other diuretics; with acute pulmonary edema; cerebral edema.
It has a moderate antihypertensive effect; with hypertension can be used in combination with antihypertensive drugs.
Assign inside, starting with 0.05 g (50 mg), increasing, if necessary, the daily dose of the drug to 0.1 - 0.2 g. Usually take the entire dose in the morning (after eating).
The diuretic effect is often more pronounced if the drug is not taken daily, but with a break of 1 to 2 days.
Intravenously (0.05 g) is administered in cases where a quick effect is required (see Furosemide).
With prolonged use of the drug, hypokalemia and hypochloremic alkalosis may occur. The simultaneous use of potassium-sparing diuretics enhances the diuretic effect of the drug and reduces hypokalemia and alkalosis.
Ethacrylic acid is worse tolerated than furosemide, especially in patients with renal failure.
When using the drug, dizziness, weakness, dyspepsia, diarrhea are possible.
Treatment should be carried out against a diet rich in potassium, and if necessary, prescribe potassium preparations.
Contraindications are the same as for dichlothiazide. The drug is not recommended for anuria and pregnant women. Young children are prescribed only in exceptional cases (with resistance to other diuretics). With cirrhosis of the liver, the use of the drug requires careful medical supervision.
Method of production: tablets of 0.05 g in a package of 20 pieces; in ampoules containing 0.05 g of sodium salt of ethacrine acid, which is dissolved in an isotonic solution of sodium chloride or glucose.
Storage: List B.