Medication Description: Legalon (Legalon)
LEGALON (Legalon) *.
The drug containing the active ingredients of the fruit of the plant is milk thistle (sharp-spotted; Silybum marianum L.).
In 1969, a group of flavonoid compounds with a hepatotropic effect was isolated from these fruits (Fructus Cardui mariae). This group of compounds was designated silymarin (Silimarin). Subsequently, three separate isomeric compounds were isolated from silymarin: silibinin, silidianin, and silicristin. All three compounds have a phenylchromanone structure and possess, to varying degrees, hepatoprotective activity.
Legalon is a total preparation containing silymarin, silibinin and milk thistle fruit extract.
Similar in composition and action of drugs produced in different countries under different names: Kars, Apihepar, Carsil, Dorogan, Duricol, Hepadestal, Laragon, Silarine, Silgen, Silibancol, Silimarin, Silybin, Silymarin, Silymarol, Somatron, etc.
Legalon is available in the form of dragees (legalon-70), containing 70 mg of silymarin with not less than 30 mg of silibinin in 90 mg of milk thistle fruit extract; in the form of capsules (legalon-140), containing 140 mg of silymarin with not less than 60 mg of silibinin in 180 mg of milk thistle fruit extract; in the form of a suspension (legalon suspension) containing 1 g in 100 g of silymarin with not less than 0.43 g of silibinin in 1, 3 g of extract of milk thistle fruit.
Legalon is used in acute (toxic) hepatitis, for maintenance therapy in chronic liver diseases and in liver cirrhosis.
Hepatoprotective effect of silymarin (silibinin) is explained by antioxidant activity (inhibition of lipid peroxidation), stimulation of protein synthesis, and normalization of phospholipid metabolism.
Pills and capsules are taken orally, without chewing, with a small amount of liquid.
For the treatment of severe liver damage, first legalon-140 is administered 1 capsule 3 times a day, then 1 capsule 2 times a day. In less severe cases and for maintenance therapy, legalon is prescribed - 70 1-2 pills 3 times a day, then 1 pill 3 times a day. In severe cases, legalon-70 is prescribed starting from 2 tablets 3 times a day.
Suspension is prescribed at the beginning of treatment and in severe cases, 4 times a day, 1 scoop (10 ml each, containing about 100 mg of silymarin); for maintenance therapy - 1 scoop 2 times a day (about 200 mg of silymarin in total). Children in severe cases, appoint 1 scoop 3 times a day, then 1/2 scoop 3 times a day.
The drug is usually well tolerated; in some cases there is a laxative effect.
Forms of release: dragee legalon-70 for 20; 100 and 400 coated tablets; Legalon-140 - 20 and 100 capsules per pack; legalon suspension - 450 ml per pack.
Recently, the silibinin dihydrosuccinate derivative sodium salt (Legalon SIL; Legalon SIL) for intravenous infusions has been developed. The drug is proposed for use in toxic liver damage caused by poisonous mushrooms Amanita phalloides.