Description of the medicine: Legalon (Legalon)
LEGAL (Legalon) *.
A preparation containing the active ingredients of the fruit of the plant of milk thistle (spicy-motley; Silybum marianum L.).
In 1969, a group of flavonoid compounds with a hepatotropic effect was isolated from these fruits (Fructus Cardui mariae). This group of compounds has been designated as silymarin. Subsequently, three separate isomeric compounds were isolated from silymarin: silibinin, silidianin, and silicristine. All three compounds have a phenylchromanone structure and exhibit hepatoprotective activity to one degree or another.
Legalon is a total preparation containing silymarin, silibinin and extract of the fruit of milk thistle.
Complicated in composition and action, preparations are produced in different countries under various names: Carsil, Apihepar, Carsil, Dorogan, Duricol, Hepadestal, Laragon, Silarine, Silgen, Silibancol, Silimarin, Silybin, Silymarin, Silymarol, Somatron, etc.
Legalon is available in the form of dragees (legalon-70), containing 70 mg of silymarin with at least 30 mg of silibinin in 90 mg of the extract of the fruit of milk thistle; in the form of capsules (legalon-140) containing 140 mg of silymarin with not less than 60 mg of silybinin in 180 mg of extract of the fruit of milk thistle; in the form of a suspension (legalon-suspension) containing in 100 g of silymarin 1 g with not less than 0.43 g of silibinin in 1, 3 g of extract of milk thistle fruit.
Legalon is used for acute (toxic) hepatitis, for maintenance therapy for chronic liver diseases and cirrhosis.
The hepatoprotective effect of silymarin (silibinin) is explained by antioxidant activity (inhibition of lipid peroxidation), stimulation of protein synthesis, and normalization of phospholipid metabolism.
Dragees and capsules are taken orally, without chewing, with a small amount of liquid.
To treat severe liver damage, first legalon-140 is prescribed 1 capsule 3 times a day, then 1 capsule 2 times a day. In less severe cases and for maintenance therapy, legalon is prescribed - 70, 1 to 2 tablets 3 times a day, then 1 tablet 3 times a day. In severe cases, legalon-70 is prescribed starting from 2 tablets 3 times a day.
The suspension is prescribed at the beginning of treatment and in severe cases 4 times a day, 1 measuring spoon (10 ml each containing about 100 mg of silymarin); for maintenance therapy - 1 scoop 2 times a day (about 200 mg of silymarin in total). In severe cases, children are prescribed 1 scoop 3 times a day, then 1/2 scoop 3 times a day.
The drug is usually well tolerated; in some cases, a laxative effect is observed.
Forms of release: dragee legalon-70 for 20; 100 and 400 tablets in a package; legalon-140 - 20 and 100 capsules per pack; legalon-suspension - 450 ml per package.
Recently, a derivative of the sodium salt of silibinin-dihydrosuccinate (Legalon SIL; Legalon SIL) for intravenous infusion has been developed. The drug is proposed for use in toxic liver damage caused by poisonous fungi Amanita phalloides.