Description of the medicine: Dinoprost (Dinoprost)
DINOPROST (Dinoprost) *. 7- [3, 5-Dioxo-2- (3-hydroxy-1-octenyl) cyclopentyl] -5-heptenoic acid.
Dinoprost is a dosage form of prostaglandin F 2 a.
Synonyms: PGF2a, Enzaprost, Amoglandin, Enzaprost-F, Minprostin F2a, Panacelan F, Prostaglan, Prostarmon, Prostarmon F, Prostin F2a.
Dinoprost, Trometamol, (Prostaglandin F 2 a Trometamol) contains prostaglandin F 2 a in combination with 2-amino-2- (oxymethyl) propane-1, 3-diol (1: 1). According to the activity of 1, 3 μg of this drug corresponds to 1 μg of dinoprost (acid).
Dinoprost is the main representative of the group of prostaglandins used in obstetric practice. It has a pronounced stimulating effect on the smooth muscles of the uterus.
Assign to excite and stimulate the contractile activity of the uterus at various stages of pregnancy and to cause abortion.
The drug has a direct stimulating effect on the specific functional structures of myometrial cells.
Excitation of contractile activity of the uterus occurs (in contrast to the effect with the use of oxytocin, see) at any time during pregnancy, and the effect is manifested regardless of the degree of cervical dilatation.
For abortion, PGF 2 a is used for medical reasons, mainly in late pregnancy (from the 13th to the 25th week).
The main methods of administration of prostaglandins are intravenous, extraamnial, intraamnial; they are also administered intravaginally. The route of administration and dose are selected depending on the indications and tolerance. For abortion in the period up to 15 weeks, extraamnial administration is recommended, and after 15 weeks - intraamnial.
For intraamnial administration of PGF 2 a, a dose of 40 mg is recommended once, giving better results than the administration of 25 mg 2 times with an interval of 6 hours. The action of 40 mg of PGF 2 a corresponds to the action of 2.5 mg of its synthetic analogue - 15-methyl - PGF 2 a . With extraamnial administration, PGF 2 a is used, 250 to 1000 mg every 1 to 2 hours.
To stimulate labor, PGF 2 a is administered intravenously. 5 mg of the drug is diluted in 500 ml of a 5% glucose solution or isotonic sodium chloride solution and administered dropwise, starting from 10-15 drops per minute, then every 10-20 minutes the number of drops is increased by 4-5 until regular contractions appear. The maximum dose should not exceed 25 mcg / min (40 drops per minute).
PGF 2 a is also used intravaginally (5 mg every 2 hours).
Prostaglandin F2a in combination with oxytocin is sometimes prescribed for labor induction.
There is evidence of the use of prostaglandin F 2 a in the form of tablets administered intracervically (17.5 mg) to expand the cervical canal.
The use of prostaglandins is allowed only in specialized medical institutions. To obtain the optimal effect, you must carefully select the dose and route of administration. It should be borne in mind that when taking prostaglandins, various side effects are possible. Prostaglandin can cause nausea, vomiting, diarrhea, tachycardia, bronchio spasm, with intravenous administration - local irritation of the veins (phlebitis), fever.