Medication Description: Triiodthyronine Hydrochloride (Triiodthyronini hydrochloridum)
TRIYODTIRONINA HYDROCHLORIDE (Triiodthyronini hydrochloridum) *.
Synthetic drug, corresponding to the structure and action of the natural thyroid hormone (see Thyroidin); Available as hydrochloride.
Synonyms: Liothyronine, Lyothyronin, Liothyronine, Liothyroninum, Trionine, etc.
Indications for use are the same as for thyroidin. Triiodothyronine is absorbed faster and more completely than thyroidin, has a more rapid effect, since during hypothyroidism the processes of absorption are usually disturbed, the use of triiodothyronine is particularly advisable in the first stage of treatment. Initial manifestations of the drug's action in hypothyroidism are noted after 4 to 8 hours. It is often effective for resistance to thyroidin, and does not cause allergic reactions. Triiodothyronine is especially indicated in myxedematous coma.
Assign inside 1 - 3 times a day. Doses are individualized based on the age of patients, the nature and course of the disease. The drug can be used in conjunction with thyroidin. When replacing thyroidin with triiodothyronine, it is assumed that 20-40 μg (0.02-0.04 mg) of triiodothyronine correspond to 0.1 g of thyroidin.
Adults are prescribed, ranging from 5 to 25 mg per day. If necessary, the dose is gradually increased to 40 - 60 mcg, sometimes up to 100 mcg (0.1 mg) per day (in a hospital, up to 150 mcg per day).
For the treatment of myxedema coma (without coronary disorders), 100 μg is prescribed 2 times a day, then the dose is reduced.
In euthyroid endemic goiter or sporadic goiter, as well as lymphomatous thyroiditis (Hashimoto's goiter), it is advisable to add 10-20 µg of triiodothyronine to the thyroid dose.
In case of diffuse toxic goiter, triiodothyronine is used after the onset of stable remission in doses not exceeding 20 μg, in combination with antithyroid drugs.
In children with hypothyroidism and myxedema, it is advisable to add 5 to 10 μg of triiodothyronine in thyroid therapy.
Treatment with triiodothyranine, especially in case of overdose, can lead to the same complications as with thyroidin.
When using triiodothyronine in patients with coronary atherosclerosis, special caution is needed, as angina attacks are possible; initial doses should be no higher than 5 - 10 mg per day; gradual increase is permissible only under the control of an electrocardiogram. In myxedema coma in patients with coronary disorders, the doses should not exceed 10–12 µg 2 times a day.
Caution is needed in the treatment of patients with secondary hypothyroidism with insufficiency of the adrenal cortex (possible exacerbation of the effects of hypocorticism with the development of addisonic crisis).
Contraindications are the same as for thyroidin.
Form release: tablets of 20 and 50 mg.
Storage: List B. In a cool, dark place.
The drug Thyreocomb (Thyreocomb), manufactured in Germany, contains 0.01 mg of triiodothyronine in one tablet; 0.07 mg of L-thyroxine and 0.15 mg of potassium iodide.
Indications for use are the same as for thyroidin and triiodothyronine.