Description of the medicine: Triiodothyronine hydrochloride (Triiodthyronini hydrochloridum)
TRIODODYRONINE HYDROCHLORIDE (Triiodthyronini hydrochloridum) *.
The synthetic drug corresponding in structure and action to the natural hormone of the thyroid gland (see Thyroidin); available in the form of hydrochloride.
Synonyms: Lyothyronin, Lyothyronin, Liothyronine, Liothyroninum, Trionine, etc.
Indications for use are the same as for thyroidin. Triiodothyronine is more rapidly and more fully absorbed than thyroidin, it has a faster effect, since with hypothyroidism the absorption processes are usually impaired, the use of triiodothyronine is especially advisable in the first stage of treatment. The initial manifestations of the action of the drug in hypothyroidism are noted after 4 - 8 hours. It is often effective in case of thyroidin resistance and does not cause allergic reactions. Triiodothyronine is especially indicated for myxedema coma.
Assign inside 1 - 3 times a day. Doses are individualized taking into account the age of patients, the nature and course of the disease. The drug can be used in conjunction with thyroidin. When replacing thyroidin with triiodothyronine, it is assumed that 20-40 μg (0.02-0.04 mg) of triiodothyronine corresponds to 0.1 g of thyroidin.
Adults are prescribed starting with 5 - 25 mcg per day. If necessary, the dose is gradually increased to 40-60 mcg, sometimes up to 100 mcg (0.1 mg) per day (in a hospital, up to 150 mcg per day).
For the treatment of myxedema coma (without coronary abnormalities), 100 μg are prescribed 2 times a day, then the dose is reduced.
In case of euthyroid endemic goiter or sporadic goiter, as well as lymphomatous thyroiditis (Hashimoto's goiter), it is advisable to add triiodothyronine at a dose of 10 - 20 mcg to the intake of thyroidin.
In diffuse toxic goiter, triiodothyronine is used after persistent remission in doses not exceeding 20 μg, in combination with antithyroid drugs.
For children with hypothyroidism and myxedema, it is advisable to add 5 to 10 micrograms of triiodothyronine in the treatment of thyroidin.
Treatment with triiodothiranine, especially with an overdose, can lead to the same complications as with thyroidin.
When using triiodothyronine in patients with coronary atherosclerosis, special care is necessary, since angina attacks are possible; initial doses should be no higher than 5 - 10 mcg per day; a gradual increase is permissible only under the control of an electrocardiogram. In case of myxedema coma in patients with coronary disorders, the dose should not exceed 10 - 12 mcg 2 times a day.
Caution is necessary in the treatment of patients with secondary hypothyroidism with adrenocortical insufficiency (an exacerbation of the phenomena of hypocorticism with the development of an addison crisis is possible).
Contraindications are the same as for thyroidin.
Release form: tablets on 20 and 50 mkg.
Storage: List B. In a cool, dark place.
The drug Thyreocomb manufactured in Germany (Thyreocomb) contains in one tablet 0.01 mg of triiodothyronine; 0.07 mg L-thyroxine and 0.15 mg potassium iodide.
Indications for use are the same as for thyroidin and triiodothyronine.