Medication Description: Glipizide (Glipizide)
GLIPIZID (Glipizide). 1-Cyclohexyl-3- [[para-2- (5-methylpyrazinecarboxamide) ethyl] phenyl] sulfonyl] urea.
Synonyms: Minidiab, Glibenese, Glucotrol, Glydiazinamide, Melizid, Menodiab, Mindiab, Minibetic, Minidiab, Minodiab.
The chemical structure and action is very close to glibenclamide.
Well absorbed. The maximum concentration in the blood is observed 1 to 2 hours after administration. It has a short half-life (3-4 hours at 5-7 hours in glibenclamide and 30-40 hours in chlorpropamide). Quickly excreted from the body, and therefore the danger of cumulation is reduced.
Indications for use are the same as for other antidiabetic sulfonylurea derivatives (type II diabetes).
The initial dose is usually 2, 5 - 5 mg (1/2 - 1 tablet) per day, further increase the dose by 1/2 - 1 tablet until the optimum maintenance dose is reached.
The maximum dose is 30 mg (6 tablets) per day. Small doses are taken once a day, doses over 15 mg in 2 to 3 doses.
Contraindications and precautions are the same as when applying glibenclamide, butamida.
Product form: tablets of 0.005 g (5 mg) in a package of 30 pieces.