Description of the medicine: Hydrocortisone (Hydrocortisonum)
HYDROCORTISON (Hydrocortisonum). 17-hydroxycorticosterone.
The chemical structure of hydrocortisone differs from cortisone by the presence of a hydroxyl and a hydrogen atom instead of oxygen at a carbon atom in position C 11.
In medical practice, hydrocortisone (free alcohol), hydrocortisone acetate, hydrocortisone succinate (hemisuccinate) are used.
Synonyms of hydrocortisone: Cobadex, Cortef, Cortil, Cortisol, Genacort, Hydrocortal, Hydrocortone, etc.
According to the effect on the body, hydrocortisone is close to cortisone, but somewhat more active. The amount of the drug when taken orally and injected into the muscles is 2/3 of the dose of cortisone.
Possible side effects, precautions and contraindications are the same as for cortisone.
Hydrocortisone (free alcohol) for oral administration is rarely used. It is used mainly for the manufacture of dosage forms.
Microcrystalline suspension of hydrocortisone (Suspensio Hydrocortisoni 25%)
It is used for intraarticular (and periarticular) administration for arthritis of rheumatic and other origin (with the exception of purulent, tuberculous and gonorrhea), bursitis, tendovaginitis, etc.
5–25 mg (0.2–1 ml of suspension) is injected into the joint cavity, depending on the size of the joint and the severity of the lesion, once a week (up to 3–5 injections per course).
Release form: in bottles on 5 ml of a suspension containing 125 mg of hydrocortisone acetate. Before use, the contents of the vial are thoroughly shaken.
It is made in Hungary.
Hydrocortisone ointment 1% (Unguentum hydrocortisoni 1%). The ointment is yellowish white.
They are used for inflammatory and allergic skin diseases of a non-microbial etiology: allergic and contact dermatitis, eczema, neurodermatitis, etc. They are applied to the affected skin with a thin layer 2 to 3 times a day.
The use of ointment is contraindicated in infectious skin diseases: tuberculosis, pyoderma, mycoses, as well as ulcerative skin lesions and wounds.
Release form: in aluminum tubes of 10 g.
Storage: in a cool, dry place.
Hydrocortisone is part of the aerosol antibacterial drug << Oxycort>> (see).