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Medication Description: Prednisolonum

Prednisolone (Prednisolonum).

Pregnadien-1, 4-triol-11b, 17a, 21-dione-3, 20, or - dehydrohydrocortisone.

Synonyms of Antisol Prednisolone, Prenolone, Sterane, Sterolone, Ultracorten H, etc.

White or white with a faint yellowish sheen crystalline powder. Practically insoluble in water, soluble in alcohol.

Prednisolone is a dehydrated analogue of hydrocortisone.

By the nature of the action and activity is close to prednisone. Applied with rheumatism, infectious nonspecific polyarthritis, bronchial asthma, acute lymphatic and myeloid leukemia, infectious mononucleosis, neurodermatitis, eczema and other indications for the use of glucocorticosteroids.

There is evidence of the effectiveness of prednisone in cirrhosis of the liver, chronic glomerulonephritis. Developed methods for the use of prednisolone (and other glucocorticosteroids) for myasthenia.

Assign prednisone inside the pill form. Usually taken, starting (in acute cases) from 20 to 40 mg per day. In the future, the dose is reduced to 5-10 mg per day. These doses are supportive. Stop treatment (as with the use of other glucocorticoids) should be gradually reducing the dose. And at the end of treatment, corticotropin should be injected 1 - 2 times.

Higher doses for adults inside: single 0,015 g daily 0.1 g.

Contraindications to the use of drugs prednisone are the same as for other glucocorticosteroids.

Product form: tablets with a content of 0.001 and 0.005 g (1 and 5 mg) of prednisolone.

Storage: List B. In the dark spot.

In urgent cases requiring an immediate increase in the level of corticosteroids in the blood (acute adrenal insufficiency, shock, asthma, asthma attacks, etc.), use the soluble drug prednisolone for injection - prednisolonemisuccinate (see).

For topical use in skin diseases of non-microbial etiology (eczema, pruritus, dermatitis, etc.) apply 0.5% prednisolone ointment (Unguentum Prednisoloni 0.5%), which is applied in a thin layer on the skin 1 - 3 times a day.

Form release: in aluminum tubes of 10 and 20 g.

Storage: List B. In a cool place.

Prednisolone is included in the ointment << Dermozolon >> (see) and the preparation << Presocyl> (see Hingamin).

In eye practice (keratitis, conjunctivitis, iritis, blepharitis, etc.), eye drops containing a 0.3% solution of 21- (deoxy-N-methyl-N'-piperazinyl) -prednisolone hydrochloride are used. Assign 1 to 2 drops 1 to 3 times a day.

Product: in bottles of 5 ml.

The drug is available in Hungary.

Possible side effects and contraindications when using eye drops with prednisone are the same as when using eye drops with dexamethasone (see).

In otorhinolaryngological practice, ear drops are used, containing in 5 mg of 0.025 g of hydrochloride 21 (deoxy-N-methyl-N'-piperazinyl) prednisolone, 0.05 g of ephedrine hydrochloride and 0.025 g of local anesthetic lidocaine.