Medication Description: Deoxycorticosterone Trimethyl Acetate (Desoxycorticosteroni trimethylacetas)
Desoxycorticosterone trimethyl acetate (Desoxycorticosteroni trimethylacetas).
Pregnen-4-ol-21-dione-3, 20-trimethyl acetate.
Synonyms: Desoxycorticosteronum trimethyl-aceticum, Percorten M.
White crystalline powder, practically insoluble in water, slightly soluble in alcohol.
By structure and biological action of deoxycorticosterone, trimethyl acetate is close to deoxycorticosterone acetate (DOCA). Chemically different from the latter in that the hydrogen atoms of the methyl group in the C 21 position are replaced by three methyl groups. In addition, when administered intramuscularly in the form of a specially prepared suspension gives a long-lasting effect. Like DOXA, deoxycorticosterone, trimethyl acetate is a synthetic analogue of the hormone of the adrenal cortex, deoxycorticosterone; belongs to the mineralocorticosteroid group.
Indications for use of deoxycorticosterone trimethyl acetate are the same as for DOXA: Addison's disease, relative insufficiency of the adrenal cortex, hypotonic syndrome, asthenic conditions with hypertension after infectious diseases, diencephalic-pituitary insufficiency, etc.
Introduce the drug intramuscularly in the form of an aqueous 2, 5% suspension of 1 ml. Injections produce 1 time in 2 weeks. Treatment should be under the supervision of a physician. Overdose can cause edema (due to sodium and water retention), an increase in blood pressure. In these cases, it is necessary to reduce the dose and limit the use of sodium chloride and liquid. In order to avoid the development of hypokalemia, patients should eat foods rich in potassium (fruits, vegetables). With the development of hypokalemia prescribed potassium salts (chloride or acetate) 0.5 - 1, 0 g 2 - 3 times a day.
Contraindications to the use of deoxycorticosterone trimethyl acetate are hypertension, heart failure with congestion, kidney disease with impaired function, liver cirrhosis.
Product form: 2, 5% suspension in 1 ml ampoules (25 mg of the drug).
Before use, the vials are thoroughly shaken until a uniform suspension is formed.
Storage: List B. In a cool, dark place.
Rp .: Susp. Desoxycorticosteroni trimethylacetatis 2, 5% 1 ml
DtdN 6 in ampull.