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Description of the medicine: Deoxycorticosterone trimethylacetate (Desoxycorticosteroni trimethylacetas)

DEOXYCORTICOSTERONE TRIMETHYL ACETATE (Desoxycorticosteroni trimethylacetas).

Pregnen-4-ol-21-dione-3, 20-trimethyl acetate.

Synonyms: Desoxycorticosteronum trimethyl-aceticum, Percorten M.

White crystalline powder, practically insoluble in water, slightly soluble in alcohol.

In terms of the structure and biological effect of deoxycorticosterone trimethyl acetate is close to deoxycorticosterone acetate (DOXA). Chemically different from the latter in that the hydrogen atoms of the methyl group in position C 21 are replaced by three methyl groups. In addition, when administered intramuscularly in the form of a specially prepared suspension gives a lasting effect. Like Doxa, deoxycorticosterone trimethyl acetate is a synthetic analogue of the adrenal cortex hormone deoxycorticosterone; belongs to the group of mineralocorticosteroids.

Indications for the use of deoxycorticosterone trimethyl acetate are the same as DOXA: Addison’s disease, relative adrenal cortex insufficiency, hypotonic syndrome, asthenic states with hypertension after infectious diseases, diencephalic-pituitary insufficiency, and others. If necessary, use deoxycorticosterone trimethylacetosterone in combination.

The drug is administered intramuscularly in the form of an aqueous 2.5% suspension of 1 ml. Injections produce 1 time in 2 weeks. Treatment should be carried out under the supervision of a physician. An overdose can cause swelling (due to the delay of sodium and water), an increase in blood pressure. In these cases, it is necessary to reduce the dose and limit the use of sodium chloride and fluids. In order to avoid the development of hypokalemia, patients should eat foods rich in potassium (fruits, vegetables). With the development of hypokalemia, potassium salts (chloride or acetate) are prescribed at 0.5 - 1, 0 g 2 - 3 times a day.

Contraindications to the use of deoxycorticosterone trimethyl acetate are hypertension, heart failure with congestion, kidney disease with impaired function, cirrhosis.

Release form: 2, 5% suspension in ampoules of 1 ml (25 mg of the drug).

The ampoules are thoroughly shaken before use until a uniform suspension is formed.

Storage: List B. In a cool, dark place.

Rp .: Susp. Desoxycorticosteroni trimethylacetatis 2.5% 1 ml

DtdN 6 in ampull.

S.