Description of the medicine: Sighetin (Sygethinum)
The dipotassium salt of meso-3, 4-di (para-sulfophenyl) -hexane.
White crystalline powder. It is slightly soluble in water (1: 50), easily soluble in hot water, insoluble in alcohol.
Aqueous solutions can be sterilized by conventional methods.
The structure of sigetin is similar to synestrol, but does not have an estrogenic effect; however, due to the effect on the gonadotropic function of the pituitary gland and on the hypothalamic centers, it is effective in mild climacteric disorders.
The drug enhances uterine contractions, improves placental circulation.
Sigetin is used to accelerate labor, prevent and treat fetal asphyxiation.
If there are signs of threatening or intrauterine asphyxiation of the fetus, the woman in labor is injected intravenously with 2 - 4 ml of a 1% sigetin solution (preferably in 20 - 40 ml of a 20% glucose solution). Injections can be repeated after 30 minutes - 1 hour (no more than 5 times).
The drug is also used dropwise in an isotonic sodium chloride solution.
To prevent intrauterine threatening fetal asphyxiation, a pregnant woman is injected intramuscularly or intravenously with 1 - 2 ml of 1% solution daily for 10 days and in the last week of pregnancy with 3-4 ml of 1% solution.
The drug is also used for menopausal disorders in women. Assign inside by 0.05 - 0.1 g (regardless of the meal time). The daily dose is 0.1 - 0.2 g. The course of treatment is 30 - 40 days.
The use of cigetin during childbirth is contraindicated in case of massive blood loss in the woman in labor and premature detachment of the placenta.
Method of release: tablets of 0.05 and 0.1 g, 1% solution in ampoules of 1 and 2 ml.
Storage: List B. In a dry, dark place.