Medication Description: Sigetin (Sygethinum)
The meso-3,4-di (para-sulfophenyl) -hexane dikalium salt.
White crystalline powder. It is difficult to dissolve in water (1:50), easily soluble in hot water, insoluble in alcohol.
Aqueous solutions can be sterilized by conventional methods.
According to the structure, sigetin has a similarity with synestrol, but does not have an estrogenic effect; however, due to the effect on the gonadotropic function of the pituitary and on the hypothalamic centers, it is effective in mild menopausal disorders.
The drug enhances the reduction of the uterus, improves placental circulation.
Sypetin is used to speed up labor, prevent and treat fetal asphyxia.
If there are signs of threatening or prenatal asphyxia of the fetus, 2 - 4 ml of 1% sietin solution is injected intravenously (preferably in 20 - 40 ml of 20% glucose solution). Injections can be repeated after 30 minutes - 1 hour (no more than 5 times).
Also used drug drip in isotonic sodium chloride solution.
For the prevention of intrauterine threatened asphyxia, a pregnant woman is intramuscularly or intravenously injected with 1 to 2 ml of 1% solution daily for 10 days and in the last week of pregnancy 3 to 4 ml of 1% solution.
The drug is also used in menopausal disorders in women. Assign inside of 0.05 - 0.1 g (regardless of the time of a meal). Daily dose of 0.1 - 0.2 g. The course of treatment is 30 - 40 days.
The use of sigetin during childbirth is contraindicated for massive blood loss in the parturient woman and premature detachment of the placenta.
Method of production: tablets of 0.05 and 0.1 g, 1% solution in 1 and 2 ml ampoules.
Storage: List B. In a dry, dark place.