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Description of the medicine: Pregnin (Praegninum)

PREGNIN (Praegninum).

Pregnen-4-in-20-ol-17 b-on-3, or 17 a - ethinyltestosterone.

Synonyms: Aethisteronum, Ethisterone, Ethisteronum, Gestone-Oral, Lutocycol, Nalutron, Oraluton, Pranone, Pregneninolone, Pregnoral, Progestoral, Proluton C, etc.

Crystalline powder, white or white with a yellowish tint. It is practically insoluble in water, very slightly soluble in alcohol, soluble in oils.

Pregnin is a synthetic analogue of the corpus luteum hormone (progesterone). The biological and therapeutic effect is similar to the action of natural hormone; however, it is less active (5-6 times) than progesterone. A feature of pregnin compared with progesterone is its ability to maintain activity and exert a therapeutic effect when taken orally or sublingually (absorption through the mucous membrane of the oral cavity).

Pregnin, like progesterone, is prescribed for ovarian dysfunction associated with corpus luteum insufficiency. With dysfunctional uterine bleeding, both pregnin and progesterone are prescribed in order to cause the endometrium to transition to a premenstrual state, which can lead to the cessation of bleeding. Pregnin is also used for amenorrhea, hypo-oligomenorrhea, algomenorrhea. Pregnin (as well as progesterone) is prescribed for the treatment of infertility after the prior use of estrogen preparations. With the usual, threatening and beginning miscarriage, pregnin is not used.

Usually prescribed is 0.01 - 0.02 g (10 - 20 mg) 2 - 3 times a day in the form of tablets under the tongue. With severe bleeding, the dose is increased to 0.05 - 0.06 g per day and pregnin is combined with androgens.

Highest doses for adults: single 0.02 g, daily 0.06 g.

A pregnin tablet must be kept under the tongue until it is completely dissolved, so that the drug is absorbed through the oral mucosa. This route of administration contributes to a more effective therapeutic effect than when taking the drug inside.

Release form: tablets on 0,01 g.

Storage: List B. In the dark place.

Rp .: Tab. Praegnini 0.01 N.20