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Medication Description: Pregnin (Praegninum)

PREGNIN (Praegninum).

Pregnen-4-yn-20-ol-17 b -it- 3, or 17 a - ethinyl testosterone.

Synonyms: Aethisteronum, Ethisterone, Ethisteronum, Gestone-Oral, Lutocycol, Nalutron, Oraluton, Pranone, Pregneninolone, Pregnoral, Progestoral, Proluton C, etc.

White or white with a yellowish sheen crystalline powder. Practically insoluble in water, very slightly soluble in alcohol, soluble in oils.

Pregnin is a synthetic analogue of the hormone of the corpus luteum (progesterone). The biological and therapeutic effects are similar to those of the natural hormone; however, it is less active (5–6 times) than progesterone. The peculiarity of pregnin compared with progesterone is its ability to maintain activity and exert a therapeutic effect when taken orally or sublingually (absorption through the mucous membrane of the oral cavity).

Pregnin, as well as progesterone, is prescribed for disorders of ovarian function associated with deficiency of the corpus luteum. In dysfunctional uterine bleeding, both pregnin and progesterone are prescribed in order to cause the endometrial transition to a premenstrual state, which can lead to the cessation of bleeding. Pregnin is also used in amenorrhea, hypooligomenorrhea, algomenorrhea. For the treatment of infertility pregnin (as well as progesterone) is prescribed after prior use of estrogen drugs. With the usual, threatening and beginning miscarriage, pregnin is not used.

Usually prescribed in 0.01-0.02 g (10-20 mg) 2 to 3 times a day in the form of tablets under the tongue. With severe bleeding, the dose is increased to 0.05-0.06 g per day and pregnin is combined with androgens.

Higher doses for adults: single 0.02 g, daily 0.06 g.

Pregnin tablet must be kept under the tongue until completely dissolved so that the drug can be absorbed through the mucous membrane of the oral cavity. This route of administration contributes to a more effective therapeutic effect than when taking the drug inside.

Form release: tablets of 0.01 g.

Storage: List B. In the dark spot.

Rp .: Tab. Praegnini 0.01 N.20