Description of the medicine: Folic acid (Acidum folicum)
FOLIC ACID (Acidum folicum). [The name "folic acid" (from folium - leaf) is due to the fact that it was originally isolated from spinach leaves.].
N- [4 - [(2-amino-1, 4-dihydro-4-oxo-6-pteridyl) methyl] amino] benzoyl L (+) - glutamic acid.
Synonyms: Vitamin B, Pteroylglutamic acid, Cytofol, Folacid, Folacin, Folamin, Folcidin, Foldine, Folic Acid, Folicil, Folsan, Folvit, Millafol, Piofolin, etc.
Folic acid is included in the group of vitamins B. It is found in fresh vegetables (beans, spinach, tomatoes, etc.), as well as in the liver and kidneys of animals. In the human body is formed by intestinal microflora.
For medical purposes, obtained synthetically. The synthetic preparation is a yellow or yellow-orange crystalline powder. Practically insoluble in water and alcohol; easily soluble in caustic alkali solutions. Hygroscopic. It decomposes in the light.
In the body, folic acid is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. It is necessary for the normal formation of blood cells, including the processes of maturation of megaloblasts and the formation of normoblasts.
The lack of folic acid inhibits the transition of the megaloblastic phase of hematopoiesis to normoblastic.
Together with vitamin B 12 it stimulates erythropoiesis, and is also involved in the synthesis of amino acids (methionine, serine, etc.), nucleic acids, purines and pyrimidines, and in the exchange of choline.
It is used to stimulate erythropoiesis in macrocytic anemia (megaloblastic anemia in pregnant women, etc.), as well as in spru. In the treatment of aplastic anemia, the drug is ineffective. With spruce, folic acid reduces or eliminates the clinical manifestations of the disease, normalizes blood formation (in this disease, cyanocobalamin and ascorbic acid, liver preparations, and hemotherapy are simultaneously prescribed). Folic acid is also used for anemia and leukopenia caused by drugs and ionizing radiation, anemia resulting from resection of the stomach and intestines, and alimentary macrocytic anemia of newborns. Due to the beneficial effect on intestinal function, it is recommended for the treatment of chronic gastroenteritis and intestinal tuberculosis.
With pernicious anemia, folic acid should be prescribed only with vitamin B 12. Although folic acid may slightly improve hematopoiesis, it does not prevent the development of neurological complications (funicular myelosis, etc.).
To prevent folic insufficiency associated with an unbalanced or unsatisfactory diet, folic acid is prescribed orally at 20-50 mcg daily. During pregnancy, take 400 mcg per day, while breastfeeding - 300 mcg.
For therapeutic purposes, adults are prescribed at 0.005 g (5 mg) per day, for children - in lower doses, depending on age. The duration of treatment is 20 to 30 days.