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Medication Description: Choline Chloride (Cholini chloridum)

CHOLINE CHLORIDE (Cholini chloridum).
(2-Hydroxyethyl) -trimethylammonium chloride.

Synonyms: Bilineurine, Choline chloride, Cholinium chloratum, Luridine.

White crystals or white crystalline powder with a characteristic smell of amines. Very hygroscopic. Very easily soluble in water, easily in alcohol. Aqueous solutions (pH of 20% solution 5, 5 - 7, 0) are sterilized at a temperature of + 100 ° C for 30 minutes.

Choline chloride is conventionally referred to as a complex of vitamins of the group B. It is a substance from which acetylcholine is formed in the body - one of the main mediators of nervous excitement.

Choline is part of the phospholipid lecithin, which is an important part of the body's cells. Plays an important role in the metabolism of phospholipids; participates in the process of phospholipid synthesis in the liver. The lack of choline in the body of animals leads to the development of fatty infiltration and hemorrhagic degeneration of the liver and kidneys, involution of the goitre gland.

Choline is one of the main representatives of the so-called lipotropic substances that prevent or reduce fatty infiltration of the liver. It also serves as an important source of methyl groups necessary for the biochemical processes occurring in the body (See also Methionine, Calcium Pangamat.).

Choline has a weak acetylcholine-like effect; slightly stimulates the intestinal muscles. In large doses, can cause the excitation of the m-cholinergic systems of the body.

A large amount of choline is found in egg yolk, liver, cereal germs, cabbage, and spinach.

The need for an adult in choline is 0.5-1.5 g per day.

As the drug used choline chloride, obtained by synthetic means.

Choline chloride is prescribed for diseases of the liver: Botkin's disease, hepatitis, cirrhosis of the liver (mainly in the early stages), hypothyroidism, cystinuria, atherosclerosis, chronic alcoholism.

Inside take in the form of a 20% solution of 1 teaspoon (5 ml) 3 - 5 times a day (3 - 5 g of choline chloride per day).

The vein is administered by the drip method in the form of a 1% solution in an isotonic solution of sodium chloride or 5% glucose solution at a rate of no more than 30 drops per minute. In one step injected up to 200 - 300 ml of solution (2 - 3 g).

Intravenous injections supplement the appointment of a 20% solution of the drug inside.

The duration of treatment depends on the condition of the patient and ranges from 7 to 10 days to 3 weeks or more with a total amount of the drug for 1 course of treatment 80-100 mg.

When ingestion occasionally observed dyspeptic symptoms. With rapid intravenous administration, a sensation of heat, nausea, sometimes vomiting, bradycardia, lowering of blood pressure, even collapse may occur. These phenomena are associated with the excitation of peripheral cholinergic systems of the body. In order to avoid their solutions of choline chloride should be injected into the vein only by the drip method in the hospital.

Method of issuance: powder; 20% solution in 10 ml ampoules; For drip infusions prepare 1% solution.