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Description of the medicine: Chymotrypsin crystalline (Chymotrypsinum crystallisatum)

CHEMOTRYPSIN CRYSTALLINE (Chymotrypsinum crystallisatum).

Chymotrypsin is a proteolytic enzyme that forms in the mammalian pancreas. For medical use, it is obtained from the pancreas of cattle. The pancreatic juice is contained in an inactive state in the form of a chymotrypsinogen (chymotrypsinogen A and B), which is activated under the influence of trypsin, and a number of forms are formed from chymotrypsinogen A: a, b, g, s and p -chymotrypsin, and chymotrypsinogen B - chymotrypsinogen B. All forms of chymotrypsin are similar in enzymatic properties, but differ in activity. The α-chemotrypsin, which is available under the name "crystalline chymotrypsin," is currently of practical importance as a medicine. a-chemotrypsin is a protein with a relative molecular weight of 21,600 - 27,000. It belongs to the group of proteolytic enzymes. Like trypsin, it hydrolyzes proteins and peptones to form relatively low molecular weight peptides. It differs from trypsin in that it cleaves mainly bonds formed by residues of aromatic amino acids (tyrosine, tryptophan, phenylalanine, methionine). In some cases, chymotrypsin produces deeper protein hydrolysis than trypsin. It differs from trypsin also in that it causes coagulation of milk. More resistant than trypsin and slower inactivation.

Crystalline chymotrypsin is a shiny flake or white powder. Soluble in water and in an isotonic sodium chloride solution; pH of 0.2% aqueous solution 4, 5 - 6, 5. In the dry form, it is resistant; aqueous solutions are rapidly inactivated, especially at high temperatures.

The use of chymotrypsin (like trypsin) in medical practice is based on the specific ability to break down necrotic tissues and fibrinous formations under local exposure, thin out viscous secrets and exudates, and, when administered intramuscularly, have an anti-inflammatory effect.

Indications for use, methods of use, doses, contraindications and possible complications are the same as for crystalline trypsin.

In addition, chymotrypsin is used for intracapsular cataract extraction.

Release form: in hermetically sealed bottles or ampoules containing 0.005 g (5 mg) and 0.01 g (10 mg) of crystalline chymotrypsin.

Storage: in a dark place at a temperature of no higher than + 10 'C.