Description of the medicine: Profezimum (Profezimum)
An enzymatic proteolytic drug (protosubtilin), which is a complex of proteases produced by you. subtilis.
Protosubtilin is immobilized on aminocellulose and is a drug of prolonged action (see Streptodecase). The finished product is available as a suspension (suspension) in an isotonic sodium chloride solution. Suspension of yellow-brown color; when standing forms a tan precipitate and a clear supernatant. Shake the suspension before use.
Profesim has the ability to hydrolyze denatured proteins, has a necrolytic effect and at the same time reduces swelling and inflammation of tissues; stimulates regenerative processes.
Profesim is prescribed for acute purulent-necrotic processes of various etiologies (suppuration of surgical wounds, purulent wounds after opening abscesses, phlegmon, mastitis, infected wounds, etc.); chronic purulent-necrotic processes (long-term non-healing wounds, trophic and radiation ulcers; chronic osteomyelitis); with intolerance to other proteolytic enzymes.
Apply only externally. The average dose is 1 ml of suspension per 1 cm 'of the wound surface. Before applying the drug, the wound is treated with the removal of pus and necrotic tissue. Apply profesim in a thin layer, gauze dressings moistened with isotonic sodium chloride solution are applied on top. As the dressings dry, they are moistened with an irrigator or a perforated polyethylene catheter is placed over 2 to 3 layers of gauze, through the outer end of which an isotonic sodium chloride solution is periodically injected with an interval of 6 to 8 hours.
The frequency of changing dressings depends on the abundance of wound discharge: with intensive dressing of dressings with wound discharge, they are changed every day with the corresponding toilet of the wound surface and applying a suspension of profesim on it. As exudation decreases, dressings can be made in 1 - 2 days. In chronic purulent-necrotic processes (trophic ulcers, etc.), dressings can be changed at intervals of up to 5 days.
In chronic osteomyelitis, the profesim is injected into the cavity after it is opened (for the lysis of undeleted purulent necrotic contents). The drug is used until the wound surface is completely cleansed of purulent-necrotic masses.
The use of profesim is contraindicated in purulent-necrotic processes complicated by bleeding.
Release form: 10% suspension of 10 ml in bottles, hermetically sealed with rubber stoppers, crimped aluminum caps.
Storage: at a temperature of + 4 to + 8 'C.