Medication Description: Profesim (Profezimum)
Enzyme proteolytic drug (protosubtilin), which is a complex of proteases produced by you. subtilis.
Protosubtilin is immobilized on amino cellulose and is a drug of prolonged action (see Streptodekaza). The finished product is produced in suspension (suspension) in isotonic sodium chloride solution. Suspended tan; when standing, it forms a yellow-brown precipitate and a clear supernatant. Before use, the suspension is stirred.
Profesim has the ability to hydrolyze denatured proteins, has a necrolytic effect and at the same time reduces swelling and inflammation of tissues; stimulates regenerative processes.
A profession is prescribed for acute purulent-necrotic processes of various etiologies (suppuration of surgical wounds, purulent wounds after opening abscesses, phlegmon, mastitis, infected wounds, etc.); chronic purulent-necrotic processes (non-healing wounds, trophic and radiation ulcers; chronic osteomyelitis); with intolerance to other proteolytic enzymes.
Apply only externally. The average dose is 1 ml of suspension per 1 cm 'of the wound surface. Before applying the preparation, the wound is treated with removal of pus and necrotic tissue. They are applied with a thin layer of profesim, and gauze bandages moistened with isotonic sodium chloride solution are applied on top. As the dressing dries, they are moistened with an irrigator, or a perforated polyethylene catheter is placed on top of 2 to 3 layers of gauze, and isotonic sodium chloride solution is periodically introduced through the outer end of the tube with an interval of 6 to 8 hours.
The frequency of dressing changes depends on the abundance of wound discharge: when the dressings are intensively soaked with wound dressings, they are changed every day with an appropriate toilet of the wound surface and a profesime suspension is applied to it. As the exudation decreases, dressings can be made in 1 to 2 days. In chronic purulent-necrotic processes (trophic ulcers, etc.), the dressings can be changed at intervals of up to 5 days.
In case of chronic osteomyelitis, the professy is introduced into the cavity after its opening (for lysis of unremoved purulent-necrotic contents). The drug is used until complete cleansing of the wound surface from purulent-necrotic masses.
The use of profezyme is contraindicated in purulent-necrotic processes complicated by bleeding.
Form release: 10% suspension of 10 ml in vials, hermetically sealed with rubber stoppers, compressed aluminum caps.
Storage: at a temperature of + 4 to + 8 'C.