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Description of the medicine: Lecozim (Lecozim)

LEKOZIM (Lecozim) *.

A proteolytic drug obtained (like caripazine) from the milky sap of a melon tree (Carica raraua L.). Like caripazine, it contains the enzymes papain, chymopapain, peptidases, as well as the mucolytic enzyme lysozyme.

Lyophilized white powder.

Activity is expressed in units of action [FIP U (from the International Pharmaceutical and Unit - Unit).] Established by the International Federation of Pharmaceuticals (FIP).

The main effect of lekozyme is associated with its proteolytic activity, however, there is a specific chondrolytic activity.

Unlike caripazine, lekozyme is used not only locally, but also parenterally.

Lekozyme was used in orthopedic and traumatological practice (for osteochondrosis of the spine, some forms of hernia of the intervertebral discs, post-traumatic contractures, for debridement of fistulas, etc.); in neurosurgical practice (pathology of the spine, cicatricial adhesions after a peripheral nerve injury, etc.); in ophthalmic practice (for resorption of exudates, with clouding of the cornea, sluggish keratitis and uveitis, clouding of the vitreous body, stale hemorrhages in the fundus, etc.). There is evidence of the drug’s ability to delay the development of cataracts. It is also prescribed for extracapsular cataract extraction.

Apply lekozyme in the form of injections, eye drops, electrophoresis methods.

Solutions prepare ex tempore; the contents of the vial are dissolved in 2 ml of sterile water for injection or a 0.5% solution of novocaine and mixed with shaking. Aqueous solutions remain active for 1 to 3 hours. Upon contact with metals, the drug is rapidly inactivated, therefore, prolonged contact of the solution with the syringe needle should not be allowed.

Lecozyme treatment requires great caution (especially in ophthalmic practice) with regard to determining the dose of the drug. Its administration in the form of injections and eye drops may be accompanied by pain and inflammation.

With increased sensitivity (itching, fever, etc.), antihistamines are used.

Lekozyme is contraindicated in acute inflammatory processes in tissues, infectious diseases, tumors, protrusion of a herniated disc in the spinal canal, pregnancy, and severe neurological disorders.

Release form: in hermetically sealed bottles in the form of lyophilized powder with proteolytic activity of 70 FIP U, 10 bottles in a package.

Storage: at a temperature of + 2 to + 8 'C. At high temperatures, the drug loses activity.

Aqueous solutions remain active for 1 to 3 hours.