This page has been robot translated, sorry for typos if any. Original content here.

Attention! The information is for reference only!
Before taking, be sure to consult a doctor!
SITE ONLY DIRECTORY. NOT A PHARMACY! We do not sell medicines! None!

Description of the medicine: Penicillinase (Penicillinasum)

PENICILLINASE (Penicillinasum).

Synonym: Neutropen.

An enzyme produced by certain types of microorganisms.

Flavourless white amorphous powder. Easily soluble in water, hygroscopic. Contains at least 50,000 units in 1 mg. For 1 unit, the smallest amount of the drug is able to inactivate 10 -7 moles (about 60 units) of benzylpenicillin in 1 ml of phosphate buffer for 1 h at a temperature of 37 ° C.

It has a specific ability to inactivate benzylpenicillin and other penicillins sensitive to this enzyme. The drug after administration has a quick effect: for a long time (4 days) it remains in the body and during this time it can have an inactivating effect.

Applied in acute allergic reactions and anaphylactic shock caused by drugs of the penicillin group (see).

Intramuscularly administered in a dose of 1,000,000 units immediately after the occurrence of an allergic reaction. If urticaria or the appearance of dermatitis do not subside after 2 days, the same dose of the drug is repeated (a total of no more than 3 injections at intervals of 2 days).

Repeated administration is necessary only with a continuing allergic reaction, which is more likely to occur with prolonged-acting penicillins (bicillins, etc.) [It is advisable to administer penicillinase at the injection site of a prolonged penicillin preparation.].

In anaphylactic shock, penicillinase (1,000,000 units) is administered immediately after removing the patient from the state of asphyxia and collapse by means generally accepted in these cases.

For intramuscular injection, dilute the contents of the ampoule or vial in 2 ml of water for injection or isotonic sodium chloride solution.

With repeated administration, penicillinase can cause sensitization of the body and allergic complications, and therefore it should not be used more than 3 times per treatment course. The drug should be prescribed only for allergic reactions caused by penicillins (and not other drugs). Penicillinase should not be used to treat occupational allergic diseases in persons engaged in the production of penicillin preparations or for a long time working with them (the drug is used in people of this category in case of acute allergic complications in the case of treatment with penicillin preparations).

Repeated injections of penicillinase are contraindicated in case of intolerance to the drug and hypersensitivity to it.

Release form: in hermetically closed bottles or in ampoules on 500 000 and 1 000 000 PIECES.

Storage at room temperature.