Description of the medicine: Ingitrilum (Ingitrilum)
The drug is obtained from the lungs of cattle.
Lyophilized powder cream or white with a grayish-yellow tint. Easily soluble in water and isotonic sodium chloride solution.
Like pantripin, it inhibits the activity of proteolytic enzymes, reduces the fibrinolytic activity of the blood.
The activity of the drug is determined by the decrease in trypsin activity and expressed in units; 1 g of the drug contains at least 550 units.
It is used to treat acute pancreatitis, exacerbations of chronic pancreatitis, and with other indications to reduce the activity of proteolytic and fibrinolytic enzymes.
Apply intravenously (jet or drip). In acute pancreatitis, it is preferable to drip the drug in order to ensure its uniform supply throughout the day at the rate of 200 units on the first day. Inhitrile is also added to the solutions administered to the patient to compensate for water losses, detoxification, etc., or the desired dose is dissolved in 500 - 1000 ml of an isotonic sodium chloride solution.
In cases of complicated acute pancreatitis, a concentrated solution of the drug (100 units in 10 to 20 ml of isotonic sodium chloride solution) is administered intravenously before the above dose is prescribed. Then the daily dose of ingitril is increased to 300 units. In the next 2-6 days, the drug is prescribed in the same dose, and if signs of a therapeutic effect appear, the daily dose can be reduced to 150-100 UNITS. After the relief of pain, vomiting, elimination of peritoneal phenomena, disappearance of intestinal paresis, cessation of tachycardia, normalization of blood and urine amylase levels, ingitrile is administered dropwise at 60 units per day for 3-4 days. If necessary, the dose is again increased to 100 - 150 PIECES per day and treatment is continued for another 2-6 days. The drug is stopped as soon as a lasting improvement is achieved. The course dose of ingitril for the treatment of acute pancreatitis varies from 600 to 5000 units.
In patients undergoing cardiopulmonary bypass, ingitrile is prescribed for the prevention and treatment of fibrinolytic bleeding, as well as for the prevention and treatment of pancreatitis, often complicating such operations. Start with a slow jet injection of 100 - 200 IU of ingitrile (in 10 - 20 ml of isotonic sodium chloride solution), then 200 IU are administered intravenously dropwise during the first 3 days of the postoperative period.
In case of gastrointestinal and other bleeding accompanied by fibrinolysis, ingitrile is administered intravenously in a dose of up to 300 PIECES per day until the bleeding stops or the fibrinolytic activity normalizes.
In pancreatic and high small intestinal fistulas, ingitrile is applied topically at a dose of 100 units.