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Description of the medicine: Lynethol (Linaetholum)

LINETOL (Linaetholum).

A preparation derived from linseed oil (Oleum Lini). Contains a mixture of ethyl esters of unsaturated fatty acids: oleic (about 15%), linoleic (about 15%) and linolenic (about 57%); the content of saturated acids is 9 to 11%.

Slightly yellowish oily fluid with a faint bitter taste. It does not mix with water, mixes in all proportions with alcohol, ether. Density 0.882 - 0.887. The acid number is not more than 3, 5, the iodine number is not less than 166.

Previously, linetol was prescribed orally for the prevention and treatment of atherosclerosis and externally for burns and radiation injuries of the skin.

The use of linetol in atherosclerosis is based on data on the ability of unsaturated fatty acids to lower blood cholesterol. Of the unsaturated fatty acids of linseed oil, linoleic and linolenic acids, which contain two and three double bonds, respectively, are essential (oleic acid has only one double bond). These and related polyunsaturated fatty acids (arachidonic and others; see Arachiden) play an important role in the metabolism of lipids in the body.

It is proposed to combine them conditionally in a group called "Vitamin F". Linolenic and arachidonic acids are currently given particular importance, since they are natural precursors of prostaglandins (see).

Ethyl esters of linseed oil acids in the form of the drug “Linetol” have the same effect as acids, but have better organoleptic properties and are better tolerated, especially with prolonged use.

It was noted that in some patients with atherosclerosis and other diseases that occur with hypercholesterolemia, when treating with linetol, the serum cholesterol level slightly decreases, the cholesterol / phospholipids coefficient decreases, as well as the content of β-lipoproteins and β-globulins, the level of albumin increases. Patients feel better.

Due to the lack of effectiveness in atherosclerosis, linetol has recently ceased to be used as a lipid-lowering agent, but it is used externally for burns, radiation injuries of the skin, etc. Treatment is carried out by the open method (mainly in a hospital), lubricating the affected surface with an even layer of the drug 1 time per day, or in a closed way: after applying the drug, apply a bandage with an emulsion of fish oil. The upper layer of the dressing is changed daily, and the lower 1 - 2 layers of gauze do not change, but they are impregnated with linoleum and a fresh dry dressing is applied on top. 5% linoleum ointment (Unguentum Linaetholi 5%) is also used.

Lynetol is part of the aerosol preparations Vinisol, Levovinisol, Livian and Lifuzol.

Release form: in bottles of orange glass on 100 and 180 ml.

Storage: in the dark place. Vials should not be left open to avoid damage to the drug.