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Medication Description: Linaetholum

LINEOL (Linaetholum).

The drug is derived from flaxseed oil (oleum lini). Contains mixtures of ethyl esters of unsaturated fatty acids: oleic (about 15%), linoleic (about 15%) and linolenic (about 57%); the content of saturated acids is 9–11%.

Slightly yellowish, oily, mobile liquid with a weak bitter taste. Does not mix with water, mixes up in all ratios with alcohol, ether. Density 0.882 - 0.887. Acid number not more than 3, 5, iodine number not less than 166.

Previously, linetol was administered orally for the prevention and treatment of atherosclerosis and externally for burns and radiation injuries of the skin.

The use of lineetol in atherosclerosis is based on data on the ability of unsaturated fatty acids to lower blood cholesterol. Of the unsaturated fatty acids of flaxseed oil, linoleic and linolenic acids are important in this respect, containing, respectively, two and three double bonds (oleic acid has only one double bond). These and related polyunsaturated fatty acids (arachidonic and others; see. Arachidin) play an important role in the metabolism of lipids in the body.

It was proposed to merge them conditionally into a group called "Vitamin F". Linolenic and arachidonic acids are currently of particular importance, as they are natural precursors of prostaglandins (see).

The ethyl esters of flaxseed oil in the form of the drug "Linetol" have the same effect as acids, but have better organoleptic properties and are better tolerated, especially with prolonged use.

It is noted that in some patients with atherosclerosis and other diseases that occur with hypercholesterolemia, treatment with lineetol slightly decreases serum cholesterol, decreases cholesterol / phospholipid ratio, and also levels of β-lipoproteins and b -globulins, increases albumin levels. The health of patients improves.

Due to the lack of effectiveness in atherosclerosis, linetol has recently ceased to be used as a hypolipidemic agent, but it is used externally for burns, radiation lesions of the skin, etc. The treatment is carried out in an open way (mainly in the hospital), lubricating the affected surface with an even layer of the drug 1 time day, or in a closed way: after applying the drug bandage with emulsion of fish oil. The top layer of the dressing is changed daily, and the bottom 1 - 2 layers of gauze do not change, but they are impregnated with lineol and a fresh dry dressing is applied on top. Also apply 5% liniteol ointment (Unguentum Linaetholi 5%).

Linetol is part of the aerosol preparations "Vinizol", "Levovinisol", "Livian" and "Lifusol".

Product: in orange glass bottles of 100 and 180 ml.

Storage: protected from light. Vials should not be left open to prevent damage to the drug.