Means that relax the muscles of the uterus (tocolytics)

To reduce the contractile activity of the uterus (mainly in
Threat of premature birth) use a variety of medicines
Neurotropic and myotropic action (sedatives, cholinolytics,
Antispasmodics, etc.). In recent years, for this purpose,
A b -adrenostimulators. The basis for this was data on the role of adreno-
Receptors in the regulation of uterine contractility and the possibility of
Regulation of this activity with substances that stimulate or block
Aa - and A b-adrenoceptors.
It was established that activation of Aa-adrenoreceptors and blockade of Ab-adrenoreceptor-
The a-blockade of α-adrenoceptors or stimulation
A b-adrenoreceptors - to inhibition of uterine contractile function.
The inhibitory effect on the myometrium is exerted by various A b-adrenomimetics
(Isadrine, orciprenaline, fenoterol, salbutamol, terbutaline, etc.).
The experience of studying A b-adrenomimetics shows that they also improve
Uteroplacental circulation (not only through relaxation
Myometrium, but also due to the expansion of arterioles and increased blood flow).
The introduction of Ab-adrenostimulants as tocolytic agents
For prevention and therapy of threatening abortion
Was a major contribution to obstetric-gynecological practice.