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Antiandrogens include a number of steroid and nonsteroidal compounds that can suppress the physiological activity of endogenous androgens. Their action is associated with competitive blocking of androgen receptors in target tissues; they do not violate the biosynthesis and secretion of androgens.
Antiandrogenic activity is characteristic to varying degrees, a number of endogenous steroid compounds, including progestin, estrogen and their synthetic derivatives, as well as some androgen derivatives. Of the steroid compounds, cyproterone acetate is best known as an antiandrogen. In the 70s, there were reports of high antiandrogenic activity of nonsteroidal compounds - carboxyanilide derivatives of flutamide, etc.
In medical practice, antiandrogens have found primary use in the treatment of prostate cancer. They are also prescribed for hyperandrogenic conditions in women (hirsutism, baldness, etc.) and in children (with early puberty).
They also use antiandrogens for the functional diagnosis of endocrine diseases.
The domestic analogue of flutamide is niftolide (Niphtholidum).