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Local anesthetic drugs

Preparations containing poisons of bees and snakes, are used to reduce pain and inflammation in polyarthritis, myositis, radiculitis and other inflammatory processes, sometimes as desensitizing agents for allergic diseases or "resolving" means for scarring changes in tissues, etc.
The mechanism of action of these drugs is not well understood. Partially, the effect is due to receptor irritation and reflex reactions, but the specific effect associated with the presence of a number of highly active substances (histamine, enzymes, micro elements, organic acids, etc.) that affect the body’s regulatory processes, including immunological reactions, to microcirculation, blood clotting, etc. The presence of the enzymes hyaluronidase and phospholipase A in the poisons of bees and snakes facilitates their penetration through the skin during local application.
The introduction of these drugs under the skin or intracutaneously causes a local and general reaction, the degree of which depends on the dose and individual sensitivity. Local reaction is expressed in the sensation of pain, burning, hyperemia, local temperature increase and swelling of tissues; general - in discomfort; chills, headache, nausea, vomiting, fever. In case of hypersensitivity, there may also appear swelling of tissues, urticaria, pain in the region of the heart, heartbeat, increased heart rate, lower back pain, joints, chills, convulsions, fainting, etc.
In case of individual selection of doses, taking into account the sensitivity to the drug, adverse reactions may not be observed, but if they are expressed, then antiallergic (antihistamine) drugs should be prescribed or the drug should be canceled. To prevent complications, it is necessary to determine the sensitivity of the patient with the introduction of small doses. It should be borne in mind that women (especially during menstruation and pregnancy), children and the elderly are hypersensitive to drugs in this group.
General contraindications to the use of bee venom preparations: individual intolerance, diseases of the kidneys, liver and pancreas; neoplasms, tuberculosis; severe infectious diseases, sepsis and purulent (acute) processes, diseases of the hematopoietic system, circulatory failure with decompensation, mental illness, cachexia, diabetes, damage to the adrenal cortex, pregnancy.