Hormone. prep., their antagonists, used primarily in the treatment of cancer
In oncological practice, a number of hormonal drugs are used,
primarily androgens (see. Preparations of male sex hormones -
Testosterone, etc.), estrogens (see. Preparations of female sex hormones -
Estron and others.), Corticosteroids (see Adrenal cortex preparations -
Cortisone and others.). Recently, the proliferation of drugs
inhibitory effects of estrogens (anti-estrogens) and androgens (anti
androgens). Some drugs (chloditan, aminoglutethimide) specifically
inhibit the secretion of adrenal glucocorticosteroids (cortisol).
These drugs are used mainly in hormone-dependent tumors.
Estrogens are prescribed when suppression of the action in the body is shown.
or enhancement of estrogen activity (in prostate cancer
Shl). Androgens are used when an increase in the activity of androgens is shown.
or a decrease in estrogen activity (in breast cancer, etc.).
In breast cancer and uterus cancer, progestins are also used (hydroxyprogestion
theron caproate, medroxyprogesterone acetate, megestrol acetate). When
Reduced glucocorticosteroid secretion is shown (in Itsenko’s disease,
Cushing, etc.), use adrenal blockers.
Glucocorticosteroids, due to their lympolytic action and ability
inhibit mitosis of lymphocytes, used mainly in acute
leukemia (mainly in children) and malignant lymphomas.
According to the mechanism of action, hormonal drugs differ from cytotoc-
sic anticancer drugs. Their main role is recovery
impaired humoral regulation of cell function. However, it is possible
their specific effect on tumor cells is
degrees inhibit cell division and contribute to their differentiation. Est
rogena stimulates the formation of liver globulin that binds androgens
and reducing the concentration of free, circulating testosterone; they are ugly
there is also no 5-Aa-reductase, i.e. reduce the conversion of testosterone to di-
hydrotestosterone, which plays an important role in the development of the tumor process.
Estrogens inhibit the release of lutein from the anterior pituitary gland.
hormone, which leads to a decrease in the production of test androgens
An important role in the mechanism of the antitumor action of hormones is
their binding to their specific receptors, the presence of which
found not only in normal target tissues, but also in some tumors
Antitumor effect is given with appropriate hormone-dependent
tumors different estrogenic, androgenic and other hormonal drugs
you. However, for practical application in oncology a number of drugs have been selected.
ratov with the most <beneficial> therapeutic and toxicological
- Aminoglutethimide (Aminoglutethimide)
- Anastrozole (Anastrozole)
- Bicalutamide (Bicalutamide)
- Letrozole (Letrozole)
- Medroxyprogesterone Acetate (Medroxyprogesterone acetate)
- Medrotestrone propionate (Medrotestroni propionas)
- Polyestradiol phosphate (Polyestradiol phosphate)
- Proloteston (Prolotestonum)
- Tamoxifen (Tamoxifenum)
- Toremifene (Toremifene)
- Finasteride (Finasteride)
- Flutamide (Flutamide)
- Phosphostrol (Phosphoestrolum)
- Cyproterone (Cyproterone acetate)
- Estracyt (Estracyt)