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Plasma Substitution and Detoxification Solutions

For plasma replacement in acute blood loss, shock of various kinds
walking, microcirculation disorders, intoxications and other processes,
associated with a change in hemodynamics, often use the so-called plasma
substituting solutions. Sometimes they are also called blood substitutes. One-
to, these drugs do not perform the function of blood, since they do not contain
ny elements of blood (if they are not specially added). They are also not
are sources of energy reserves (unless specifically
added energy substances - glucose, amino acids, etc.).
By functional properties and purpose, plasma-substituting solutions
They are divided into a number of groups: a) hemodynamic; b) detoxification; c) regulation
lyators of water-salt and acid-base equilibrium.
Hemodynamic drugs are mainly intended for the treatment and
prevention of shock of various origins, normalization of arterial
pressure and improvement in general hemodynamic parameters. They have from-
a relatively large molecular weight close to the molecular weight of al-
blood bumin, and when introduced into the blood stream, circulate for a long time
in the bloodstream, maintaining blood pressure at the required level.
The main representative of this group is polyglucin.
Polyglukin is one of the plasma substitutes containing a solution of
glucose meter - dextran. Dextran may have varying degrees of poly-
differentizations and, accordingly, different molecular weights; from it may be
respectively, blood-substituting (plasma-replacing) solutions of various
functional purpose.
Solutions containing dextran with a relative molecular weight of about
60,000 are used as hemodynamic agents, and with a smaller molecule
with a molar mass (30,000 - 40,000) - as a detoxification agent. Afterbirth-
nie contribute to the restoration of blood flow in small capillaries, reduce
aggregation of blood cells. When introduced into the blood stream, they enhance
the processes of moving fluid from tissues into the bloodstream, increase di
cut and, standing out by the kidneys, contribute to detoxification processes. Submit-
The body of detoxification solutions containing dextran is re-poly-
glukin. As detoxification and hemodynamic agents along with
other substances with relatively
high polymer mass (polyvinylpyrrolidone, polyvinyl alcohol,
tin, etc.).
Widespread use as detoxification solutions, as well as
solutions used for the regulation of water-salt and acid-base
equilibrium, have isotonic sodium chloride solution and other salt